IP Library Granted Patent US 8,897,535
Granted Patent B2
US 8,897,535 · App. 14/044,959 · Granted Nov 25, 2014

System and method for generating a 2D image from a tomosynthesis data set

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Quick Facts
Patent No.
US 8,897,535
App. No.
14/044,959
Granted
Nov 25, 2014
Kind
B2
Abstract

A 2D mammogram image is synthesized from at least one of tomosynthesis projection images and/or the tomosynthesis reconstructed image data. In a simplest form, the mammogram may be synthesized by selecting one of the tomosynthesis projection images for display as a synthesized mammogram. Other methods of synthesizing a mammogram include re-projecting and filtering projection data and/or reconstructed data. The synthesized mammogram is advantageously displayed together with at least a portion of the reconstructed data to aid in review of the reconstructed data. The present invention thus provides a familiar image which may be used to facilitate review of a tomosynthesis data set.

Claims (24)

1. A method comprising:

obtaining a x-ray tomosynthesis data set of a patient's breast, the x-ray tomosynthesis data set comprising at least one of tomosynthesis projection images and tomosynthesis reconstructed images;

synthesizing a two-dimensional mammogram solely from the x-ray tomosynthesis data set; and

displaying the synthesized mammogram on a display device, wherein the synthesized mammogram refers to a synthesized 2D image that simulates a conventional mammography image.

2. The method of claim 1 further comprising filtering at least one of the tomosynthesis projection images prior to the step of synthesizing.

3. The method of claim 1 further comprising reconstructing the tomosynthesis projection images into a three dimensional reconstructed image comprising a plurality of slices and displaying at least one of the plurality of slices.

4. The method of claim 3 further comprising displaying sequentially or concurrently the at least one of the plurality of slices and the synthesized mammogram.

5. The method of claim 3 further comprising processing at least some of the plurality of slices to obtain CAD marks and display the CAD marks on at least one of the plurality of slices and the synthesized mammogram.

6. The method of claim 4 , wherein the CAD marks displayed on at least one of the plurality of slices is processed and overlaid on the synthesized mammogram.

7. A method comprising:

obtaining a plurality of x-ray tomosynthesis projection images of a patient's breast;

reconstructing the plurality of x-ray tomosynthesis projection images into a three dimensional reconstructed image comprising a plurality of slices, wherein a x-ray tomosynthesis data set comprises the plurality of x-ray tomosynthesis projection images and the three dimensional reconstructed image;

synthesizing a two-dimensional mammogram using only the x-ray tomosynthesis data set in which at least a subset of the three-dimensional reconstructed image is used; and

displaying the synthesized mammogram on a display device, wherein the synthesized mammogram refers to a synthesized 2D image that simulates a conventional mammography image.

8. The method of claim 7 , wherein the step of reconstructing the plurality of x-ray tomosynthesis projection images reconstructs the x-ray tomosynthesis projection images onto a first coordinate system to provide an initial reconstruction.

9. The method of claim 8 , wherein the initial reconstruction is the three-dimensional reconstructed image.

10. The method of claim 9 , wherein the first coordinate system is selected from a group including a Cartesian coordinate system, a cone beam coordinate system and a coordinate system associated with a virtual acquisition system.

11. The method of claim 8 , wherein reconstructing the plurality of x-ray tomosynthesis projection images includes the step projecting the initial reconstruction onto a second, different coordinate system to provide the three-dimensional reconstructed image.

12. The method of claim 11 , wherein the second coordinate system is selected from a group including a Cartesian coordinate system, a cone beam coordinate system and a coordinate system associated with a virtual acquisition system.

13. The method of claim 9 , wherein reconstructing includes the step of orienting said three-dimensional reconstructed tomosynthesis image to a selected plane.

14. The method of claim 7 , wherein synthesizing includes projecting at least one tomosynthesis slice image having a pixel spacing that differs from a pixel spacing of a mammogram onto a mammogram coordinate system.

15. The method of claim 7 further comprising displaying sequentially or concurrently the at least one of the plurality of slices and the synthesized mammogram.

16. The method of claim 7 further comprising processing at least some of the plurality of slices to obtain CAD marks and display the CAD marks on at least one of the plurality of slices and the synthesized mammogram.

17. The method of claim 16 , wherein the CAD marks displayed on at least one of the plurality of slices is processed and overlaid on the synthesized mammogram.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 032059 0467 Recorded Jul 17, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 036126/0813 →
SECURITY AGREEMENT Recorded Jan 16, 2014
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 032059/0467 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 3, 2013
From: RUTH, CHRISTOPHER; SMITH, ANDREW; STEIN, JAY
To: HOLOGIC, INC.
Reel/Frame 031335/0927 →