Calcitonin products and therapies for treating inflammatory or degenerative diseases
View Patent ↗Calcitonin products and therapies for treating inflammatory or degenerative diseases are disclosed herein. The pharmaceutical compositions disclosed herein include a first therapeutic agent that is calcitonin, in free or salt form; a second therapeutic agent selected from the group consisting of a protease inhibitor, an antibiotic, a non-steroidal anti-inflammatory agent, a cyclooxygenase-2 (COX-2) inhibitor and a steroidal anti-inflammatory agent other than glucocorticoid; and a pharmaceutically acceptable excipient, carrier or diluent. The methods disclosed herein for treating inflammatory or degenerative diseases in a subject include administering a therapeutically effective amount of calcitonin, in free or salt form, to the subject; and co-administering, as part of a combination therapy, a therapeutically effective amount of a second therapeutic agent selected from the group consisting of a protease inhibitor, an antibiotic, a non-steroidal anti-inflammatory agent, a COX-2 inhibitor and a steroidal anti-inflammatory agent other than glucocorticoid to the subject.
1. A method for treating osteoarthritis in a subject in need thereof comprising: administering a therapeutically effective amount of calcitonin, in free or salt form, to the subject; and co-administering, as part of a combination therapy, a therapeutically effective amount of a tetracycline antibiotic, to the subject.
2. The method of claim 1 , wherein the calcitonin is selected from the group consisting of human calcitonin, salmon calcitonin, eel calcitonin and elcatonin.
3. The method of claim 1 , wherein the calcitonin is salmon calcitonin.
4. The method of claim 3 , wherein the subject is a human.
5. The method of claim 1 , wherein the calcitonin and the tetracycline antibiotic are each administered to the subject orally.
6. The method of claim 1 , wherein the tetracycline antibiotic is doxycycline.
7. The method of claim 6 , wherein the subject is a human.
8. The method of claim 1 , wherein the calcitonin and the tetracycline antibiotic are administered as a single pharmaceutical composition.
9. The method of claim 1 , wherein the calcitonin and the tetracycline antibiotic are administered separately.
10. The method of claim 1 , wherein the tetracycline antibiotic is administered at a dosage no higher than 90% of the normal dosage for the tetracycline antibiotic when administered alone for the treatment of osteoarthritis.
11. The method of claim 1 , wherein the subject is a human.
12. The method of claim 1 , wherein the calcitonin is salmon calcitonin and the tetracycline antibiotic is doxycycline.
13. A method for treating osteoarthritis in a human subject in need thereof comprising: administering a therapeutically effective amount of salmon calcitonin, in free or salt form, to the human subject; and co-administering, as part of a combination therapy, a therapeutically effective amount of doxycycline to the human subject.