Compounds useful in the synthesis of benzamide compounds
View Patent ↗Compounds that are useful in the synthesis of 2-amino-4,6-dimethoxybenzamide derivatives and other benzamide compounds.
1. A compound of Formula I:
wherein:
R 1 is selected from Br and CN;
R 2 is selected from H and Br;
R 3 is selected from H and
wherein
R is selected from H, CH 3 , CF 3 , CF 2 H, CFH 2 , CCl 3 , CCl 2 H, CClH 2 , CBr 3 , CBr 2 H, and CBrH 2 ; and
X is selected from O and S;
with the proviso that:
when R 1 is Br and R 2 is H, then R is not CH 3 ;
when R 1 is CN then R 2 is H; and
when R 1 is Br then R 3 is
wherein R is not H.
2. A compound according to Formula I-A:
wherein:
R is selected from CF 3 , CF 2 H, CFH 2 , CCl 3 , CCl 2 H, CClH 2 , CBr 3 , CBr 2 H, and CBrH 2 ; and
X is selected from O and S.
3. A compound according to Formula I-B:
wherein:
R is selected from H, CH 3 , CF 3 , CF 2 H, CFH 2 , CCl 3 , CCl 2 H, CClH 2 , CBr 3 , CBr 2 H, and CBrH 2 ; and
X is selected from O and S.
4. A compound according to Formula I-C:
wherein:
R is selected from H, CH 3 , CF 3 , CF 2 H, CFH 2 , CCl 3 , CCl 2 H, CClH 2 , CBr 3 , CBr 2 H, and CBrH 2 ; and
X is selected from O and S.
5. A compound selected from:
2-bromo-3,5-dimethoxytrifluoroacetanilide,
2,4-dibromo-3,5-dimethoxytrifluoroacetanilide,
2-cyano-3,5-dimethoxytrifuoroacetanilide, and
2-amino-4,6-dimethoxybenzonitrile.
6. A compound according to claim 2 , wherein X is oxygen.
7. A compound according to claim 3 , wherein X is oxygen.
8. A compound according to claim 4 , wherein X is oxygen.
9. A compound according to claim 2 , wherein R is selected from CF 3 , CF 2 H, CFH 2 , CCl 3 , CCl 2 H, and CClH 2 .
10. A compound according to claim 3 , wherein R is selected from CF 3 , CF 2 H, CFH 2 , CCl 3 , CCl 2 H, and CClH 2 .
11. A compound according to claim 4 , wherein R is selected from CF 3 , CF 2 H, CFH 2 , CCl 3 , CCl 2 H, and CClH 2 .
12. The compound according to claim 5 , wherein the compound is 2-bromo-3,5-dimethoxytrifluoroacetanilide.
13. The compound according to claim 5 , wherein the compound is 2,4-dibromo-3,5-dimethoxytrifluoroacetanilide.
14. The compound according to claim 5 , wherein the compound is 2-cyano-3,5-dimethoxytrifuoroacetanilide.
15. The compound according to claim 5 , wherein the compound is 2-amino-4,6-dimethoxybenzonitrile.