Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives
View Patent ↗Disclosed herein are salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4 inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical compositions.
1. A salt selected from the group consisting of
(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol methansulfonate; and
(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol fumarate.
2. A salt according to claim 1 which is
(2R,4a R,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol methansulfonate.
3. A salt according to claim 1 which is
(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol fumarate.
4. A pharmaceutical composition comprising one or more salts as claimed in claim 1 together with a pharmaceutical auxiliary and/or excipient.
5. A pharmaceutical composition comprising the salt as claimed in claim 2 together with a pharmaceutical auxiliary and/or excipient.
6. A pharmaceutical composition comprising the salt as claimed in claim 3 together with a pharmaceutical auxiliary and/or excipient.