IP Library › Granted Patent US 9,408,903
Granted Patent B2
US 9,408,903 · App. 14/053,426 · Granted Aug 9, 2016

Vaccination method employing genetically stable attenuated polioviruses comprising multiple mutations in domain V of the 5′ noncoding region

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Quick Facts
Patent No.
US 9,408,903
App. No.
14/053,426
Granted
Aug 9, 2016
Kind
B2
Abstract

The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5′ non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.

Claims (10)

1. A method of vaccinating a human patient against poliomyelitis, comprising administering to said patient an immunogenic composition comprising an effective amount of an inactivated or attenuated poliovirus vaccine which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5′ non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs and a pharmaceutically acceptable carrier or diluent.

2. The method according to claim 1 , wherein at least five of the base pairs in stem (b) of the 5′ non-coding region of the poliovirus genome are U-A or A-U base pairs.

3. The method according to claim 1 , wherein six of the base pairs in stem (b) of the 5′ non-coding region of the poliovirus genome are U-A or A-U base pairs.

4. The method according to claim 1 , wherein seven of the base pairs in stem (b) of the 5′ non-coding region of the poliovirus genome are U-A or A-U base pairs.

5. The method according to claim 1 , wherein two of the base pairs in stem (a) of the 5′ non-coding region of the poliovirus genome are U-A or A-U base pairs.

6. The method according to claim 1 , wherein three of the base pairs in stem (a) of the 5′ non-coding region of the poliovirus genome are U-A or A-U base pairs.

7. The method according to claim 1 , wherein said poliovirus comprises domain V of the 5′ non-coding region of poliovirus type 3 in which a U-A base pair is present at position 472-537 in stem (a) and at positions 478-533, 480-531 and 481-530 in stem (b).

8. The method according to claim 7 , in which an A-U base pair is present at position 482-529 in stem (b) of the 5′ non-coding region of the poliovirus genome.

9. The method according to claim 7 , in which an A-U base pair is present at position 477-534 in stem (b) of the 5′ non-coding region of the poliovirus genome.

10. The method according to claim 1 , wherein the poliovirus is inactivated by formaldehyde treatment.

Assignments (1)
NUNC PRO TUNC ASSIGNMENT Recorded Sep 19, 2019
From: THE SECRETARY OF STATE FOR HEALTH
To: SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE
Reel/Frame 052144/0237 →