Compositions comprising paulownia tomentosa wood extracts and uses thereof
View Patent ↗Provided are compositions comprising Paulownin or an extract of Paulownia tomentosa wood and methods of use thereof.
1. A method of improving one or more signs of skin aging and/or treating external skin aggressions comprising topically applying to skin of a subject in need thereof a composition containing a therapeutically effective amount of paulownin, wherein the improvement of one or more signs of skin aging is selected from the group consisting of improving skin firmness, skin texture, and the appearance of wrinkles.
2. The method of claim 1 , wherein said composition is in the form of a solution, suspension, lotion, cream, serum, gel, stick, spray, ointment, liquid wash, soap bar, shampoo, hair conditioner, paste, foam, powder, mousse, shaving cream, hydrogel, or film-forming product.
3. The method of claim 2 , wherein said composition further comprises a tropoelastin promoter.
4. The method of claim 3 , wherein said tropoelastin promoter is selected from the group consisting of blackberry extracts, cotinus extracts, feverfew extracts, extracts of Phyllanthus niruri and a combination thereof.
5. The method of claim 2 , wherein said composition further comprises a collagen promoter.
6. The method of claim 5 , wherein the collagen promoter is a non-retinoid collagen promoter.
7. The method of claim 6 , wherein the non-retinoid collagen promoter is selected from the group consisting of extracts of Tanacetum parthenium , extracts of Centella asiatica , extracts of Siegesbeckia orientalis , extracts of soy, and a combination thereof.
8. The method of claim 5 , wherein the collagen promoter is a retinoid.
9. The method of claim 8 , wherein the retinoid is selected from the group consisting retinol, retinal, retinyl acetate, retinyl propionate, retinyl linoleate, retinyl palmitate, and a combination thereof.
10. The method of claim 2 , wherein said composition further comprises a sunscreen.
11. The method of claim 1 , wherein improving a sign of aging comprises improving the appearance of wrinkles.
12. The method of claim 1 , wherein the composition contains paulownin in an amount from 0.1 to about 5.0% by weight of the composition.
13. The method of claim 1 , wherein the composition contains paulownin in an amount effective to reduce UV induced production of ROS in skin cells.
14. The method of claim 1 , wherein improving one or more signs of skin aging comprises improving skin firmness.
15. The method of claim 14 , wherein skin in need of improvement of skin firmness comprises skin that is sagging, loose, lax, rough, wrinkly, thinned, uneven, or a combination thereof.
16. The method of claim 11 , wherein skin in need of improvement of the appearance of wrinkles comprises skin having wrinkles, fine lines, or a combination thereof.