IP Library Granted Patent US 9,498,175
Granted Patent B2
US 9,498,175 · App. 14/057,061 · Granted Nov 22, 2016

System and method for low dose tomosynthesis

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Quick Facts
Patent No.
US 9,498,175
App. No.
14/057,061
Granted
Nov 22, 2016
Kind
B2
Abstract

A breast imaging system leverages the combined strengths of two-dimensional and three-dimensional imaging to provide a breast cancer screening with improved sensitivity, specificity and patient dosing. A tomosynthesis system supports the acquisition of three-dimensional images at a dosage lower than that used to acquire a two-dimensional image. The low-dose three-dimensional image may be used for mass detection, while the two-dimensional image may be used for calcification detection. Obtaining tomosynthesis data at low dose provides a number of advantages in addition to mass detection including the reduction in scan time and wear and tear on the x-ray tube. Such an arrangement provides a breast cancer screening system with high sensitivity and specificity and reduced patient dosing.

Claims (27)

1. A method of imaging a breast using a multi-mode mammography/tomosynthesis system, the method comprising:

acquiring a two-dimensional image of a breast using a first x-ray dose in a first mode of operation of the multi-mode mammography/tomosynthesis system, wherein the first x-ray dose is emitted from an emission source when the emission source is stationary; and

acquiring a set of tomosynthesis images of the breast in a second mode of operation of the multi-mode mammography/tomosynthesis system, wherein the set of tomosynthesis images is acquired from a plurality of projection images, wherein each of the plurality of projection images is acquired at a projection image x-ray dose less than the first x-ray dose, wherein each projection image x-ray dose is emitted when the emission source is rotating relative to the breast.

2. The method of claim 1 , wherein the two-dimensional image is acquired at an angle similar to that of a conventional mammogram.

3. The method of claim 1 , wherein the two-dimensional image is used to identify calcifications in the breast and the set of tomosynthesis images is used to identify masses in the breast.

4. The method of claim 3 , wherein identification of calcifications in the breast is accomplished via a CAD mark representative of the calcification on the two-dimensional image.

5. The method of claim 3 , wherein identification of masses in the breast is accomplished via a CAD mark representative of the masses on the set of tomosynthesis images.

6. The method of claim 1 further comprising controlling the projection image x-ray dose administered for acquisition of the set of tomosynthesis images, the controlling the projection image x-ray dose comprising adjusting at least one of an x-ray tube voltage, x-ray current, x-ray filter, exposure time, and combinations thereof.

7. The method of claim 1 further comprising controlling the projection image x-ray dose administered for acquisition of the set of tomosynthesis images, the controlling the projection image x-ray dose comprising adjusting at least one of a tomosynthesis scan angle and a number of projection images obtained for the set.

8. The method of claim 1 further comprising using an anti-scatter grid for the first mode of operation of the multi-mode mammography/tomosynthesis system.

9. The method of claim 1 , wherein the projection image x-ray dose is updated automatically in response to selection or use of the second mode of operation.

10. The method of claim 1 , wherein a total x-ray dosage of the plurality of projection images is input manually.

11. The method of claim 1 , wherein a total dosage of the plurality of projection images x-ray doses is less than the first x-ray dose.

12. A multi-mode mammography/tomosynthesis system comprising:

an x-ray source configured to move along an arc; and

an x-ray detector;

wherein the x-ray source and the x-ray detector are configured to (a) acquire a two-dimensional image of a breast using a first x-ray dose in a first mode of operation, wherein the two-dimensional image is acquired when the x-ray source is stationary and (b) acquire a set of tomosynthesis images of the breast in a second mode of operation, wherein the set of tomosynthesis images is acquired with a plurality of projection images, wherein each of the plurality of projection images is acquired at a projection image x-ray dose less than the first x-ray dose, and wherein the plurality of projection images are acquired when the x-ray source is moving along the arc.

13. The system of claim 12 , wherein the two-dimensional image is acquired at an angle similar to that of a conventional mammogram.

14. The method of claim 12 , wherein a total dosage of the plurality of projection images x-ray doses is less than the first x-ray dose.

15. A method of imaging a breast using a multi-mode mammography/tomosynthesis system, the method comprising:

acquiring a two-dimensional image of a breast using a first x-ray dose in a first mode of operation of the multi-mode mammography/tomosynthesis system, wherein the first x-ray dose is emitted from a stationary position; and

acquiring a set of projection images of the breast in a second mode of operation of the multi-mode mammography/tomosynthesis system, wherein each image of the set of projection images is acquired at a second x-ray dose less than the first x-ray dose, wherein the second x-ray dose is emitted during a rotational movement of an x-ray source that emits the x-ray.

16. The method of claim 15 , wherein the two-dimensional image is acquired at an angle similar to that of a conventional mammogram.

17. The method of claim 15 further comprising controlling the second x-ray dose administered for acquisition of the set of tomosynthesis images, the controlling the second x-ray dose comprising adjusting at least one of an x-ray tube voltage, x-ray current, x-ray filter, exposure time, and combinations thereof.

18. The method of claim 15 further comprising controlling the second x-ray dose administered for acquisition of the set of tomosynthesis images, the controlling the second x-ray dose comprising adjusting at least one of a tomosynthesis scan angle and a number of projection images obtained for the set.

19. The method of claim 15 , wherein the second x-ray dose is updated automatically in response to selection or use of the second mode of operation.

20. The method of claim 15 , wherein a total dosage of the set of projection images is less than the first x-ray dose.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 032059 0467 Recorded Jul 17, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 036126/0813 →
SECURITY AGREEMENT Recorded Jan 16, 2014
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 032059/0467 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2013
From: STEIN, JAY; SMITH, ANDREW; JING, ZHENXUE; NIKLASON, LOREN
To: HOLOGIC, INC.
Reel/Frame 031431/0810 →