MAGNETIC RELAXOMETRY USING MAGNETIZATION AND MEASUREMENT FIELDS
The present invention provides methods and apparatuses for detecting, measuring, or locating cells or substances present in even very low concentrations in vivo in subjects, using targeted magnetic nanoparticles and special magnetic systems. The magnetic systems can comprise magnetizing subsystems and sensors subsystems, including as examples SQUID sensors and atomic magnetometers. The magnetic systems can detect, measure, or location particles bound by antibodies to cells or substances of predetermined types. Example magnetic systems are capable of detecting sub-nanogram amounts of these nanoparticles.
1 . A method of measuring properties of a biological material, comprising:
combining a targeted superparamagnetic nanoparticle with the biological material;
subjecting the combination to a first magnetic field;
subjecting the combination to a second magnetic field, of lower strength that the first magnetic field;
detecting the decay of the magnetization of the superparamagnetic nanoparticles;
determining a measure of the property responsive to the detected decay.