Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
1. A compound of formula 6b:
wherein,
R is H, C 1-6 aliphatic or aralkyl;
R 1 and R 2 are independently selected from C 1-6 aliphatic, —N(R J ) 2 , —NO 2 , —CN, —C 1-4 haloalkyl, —C 1-4 haloalkoxy, —C(O)N(R J ) 2 , —NR J C(O)R J , —SOR J , —SO 2 R J , —SO 2 N(R J ) 2 , —NR J SO 2 R J , —COR J , —CO 2 R J , —NR J SO 2 N(R J ) 2 , —COCOR J ;
R J is hydrogen or C 1 aliphatic;
o is an integer from 0 to 3 inclusive; and
p is an integer from 1 to 5 inclusive.
2. The compound of claim 1 , wherein R is H.
3. The compound of claim 1 , wherein R 1 is C 1-6 aliphatic and o is 1.
4. The compound of claim 1 , wherein R 1 is methyl and o is 1.
5. The compound of claim 1 , wherein R 2 is —CO 2 R J and p is 1.
6. The compound of claim 1 , wherein R 2 is —CO 2 R J , R J is C 1-6 aliphatic, and p is 1.
7. The compound