IP Library Granted Patent US 9,585,841
Granted Patent B2
US 9,585,841 · App. 14/062,194 · Granted Mar 7, 2017

Tyrosine derivatives and compositions comprising them

Inventor: Steven Hoffman (Mahwah, NJ)
Assignee: Tyme, Inc.
A61K9/145A61K9/141A61K31/198A61K33/40A61K38/00A61K45/06A61K47/183A61N5/022A61N5/062A61N5/10
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Quick Facts
Patent No.
US 9,585,841
App. No.
14/062,194
Granted
Mar 7, 2017
Kind
B2
Abstract

Provided herein are methods comprising providing a tyrosine derivative and a solid particulate material (and, optionally, melanin) and applying force to said tyrosine derivative and said solid particulate material for a time and under conditions effective to impregnate at least one of said tyrosine derivative and said solid particulate material with the other of said tyrosine derivative and said solid particulate material. The invention also provides compositions comprising at least one of a tyrosine derivative impregnated with a solid particulate material and a solid particulate material impregnated with a tyrosine derivative.

Claims (7)

1. A method comprising:

providing a tyrosine derivative, a solid particulate material, and melanin; and

applying force to said tyrosine derivative, said solid particulate material, and said melanin for a time and under conditions effective to impregnate at least one of said tyrosine derivative and said solid particulate material with the other of said tyrosine derivative and said solid particulate material, thereby producing a particulate in which at least one of said tyrosine derivative and said solid particulate material is impregnated with the other of said tyrosine derivative and said solid particulate material.

2. The method of claim 1 further comprising adding hydrogen peroxide to said tyrosine derivative, said solid particulate material, and said melanin after applying said force to said tyrosine derivative, said solid particulate material, and said melanin.

3. The method of claim 1 wherein the tyrosine derivative is in its L-form.

4. The method of claim 1 wherein the tyrosine derivative is in its D-form.

5. The method of claim 1 wherein the tyrosine derivative is α-methyl-DL-tyrosine.

Assignments (5)
SECURITY INTEREST Recorded Dec 5, 2024
From: SYROS PHARMACEUTICALS, INC.; TYME TECHNOLOGIES, INC.; TYME INC.
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 069516/0338 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2021
From: HOFFMAN, STEVEN
To: TYME, INC.
Reel/Frame 055600/0728 →
RELEASE OF SECURITY INTEREST Recorded Jul 26, 2016
From: CKR LAW, LLP F/K/A CRONE KLINE RINDE LLP
To: TYME, INC.
Reel/Frame 039259/0800 →
SECURITY INTEREST Recorded Jul 16, 2014
From: TYME, INC.
To: CRONE KLINE RINDE LLP
Reel/Frame 033340/0630 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 10, 2014
From: HOFFMAN, STEVEN
To: TYME, INC.
Reel/Frame 033287/0730 →
Continuity (2)
Provisional Application 61894279 · Oct 22, 2013
Related Publication 20150112116A1 · Apr 23, 2015