Anti-infective binding proteins that bind AIP2
View Patent ↗There is disclosed compositions and methods relating to or derived from anti-AIP2 antibodies. More specifically, there is disclosed fully human antibodies that bind AIP2, AIP2-binding fragments and derivatives of such antibodies, and AIP2-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having AIP2 related disorders or conditions. There is also disclosed a method to treat S. aureus infections by administering an anti-AIP2 antibody described herein.
1. A fully human antibody of an IgG class that binds to S. aureus auto inducing peptide-2 (AIP2) with a binding affinity of at least 10 −6 M, wherein the antibody has a heavy chain/light chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the group consisting of SEQ ID NO. 3/SEQ ID NO. 4 (called C7 herein), SEQ ID NO. 5/SEQ ID NO. 6 (called D3 herein), SEQ ID NO. 7/SEQ ID NO. 8 (called E7 herein).
2. A Fab fully human antibody fragment that binds to S. aureus auto inducing peptide-2 (AIP2) with a binding affinity of at least 10 −6 M, wherein the antibody has a heavy chain/light chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the croup consisting of SEQ ID NO. 3/SEQ ID NO. 4 (called C7 herein), SEQ ID NO. 5/SEQ ID NO. 6 (called D3 herein), SEQ ID NO. 7/SEQ ID NO. 8 (called E7 herein).
3. A single chain human antibody that binds to S. aureus auto inducing peptide-2 (AIP2) with a binding affinity of at least 10 −6 M, having a variable domain region from a heavy chain and a variable domain region from a light chain and a peptide linker connection the heavy chain and light chain variable domain regions, wherein the antibody has a heavy chain/light chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the croup consisting of SEQ ID NO. 3/SEQ ID NO. 4 (called C7 herein), SEQ ID NO. 5/SEQ ID NO. 6 (called D3 herein), SEQ ID NO. 7/SEQ ID NO. 8 (called E7 herein).
4. A method for treating a S. aureus infection, comprising administering an effective amount of an anti-AIP2 polypeptide, wherein the anti-AIP2 polypeptide is selected from the group consisting of a fully human antibody of an IgG class that binds to S. aureus auto inducing peptide-2 (AIP2) with a binding affinity of at least 10 −6 M , wherein the antibody has a heavy chain/light chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the croup consisting of SEQ ID NO. 3/SEQ ID NO. 4 (called C7 herein), SEQ ID NO. 5/SEQ ID NO. 6 (called D3 herein), SEQ ID NO. 7/SEQ ID NO. 8 (called E7 herein); a Fab fully human antibody fragment, wherein the antibody has a heavy chain/light chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the group consisting of SEQ ID NO. 3/SEQ ID NO. 4 (called C7 herein), SEQ ID NO. 5/SEQ ID NO. 6 (called D3 herein), SEQ ID NO. 7/SEQ ID NO. 8 (called E7 herein); and a single chain human antibody, having a variable domain region from a heavy chain and a variable domain region from a light chain and a peptide linker connection the heavy chain and light chain variable domain regions, wherein the antibody has a heavy chain/light chain variable domain sequence that is at least 95% identical to the amino acid sequences selected from the group consisting of SEQ ID NO. 3/SEQ ID NO. 4 (called C7 herein), SEQ ID NO. 5/SEQ ID NO. 6 (called D3 herein), SEQ ID NO. 7/SEQ ID NO. 8 (called E7 herein).
5. The method for treating a S. aureus infection of claim 4 , wherein the S. aureus infection is caused by MRSA.