Pharmaceutical compositions
Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.
1. A pharmaceutical composition, the pharmaceutical composition consisting of:
about 8% triamcinolone;
about 2.3% sodium hyaluronate;
about 0.6% sodium chloride;
about 0.3% dibasic sodium phosphate;
about 0.04% monobasic sodium phosphate;
water, and
no added preservative.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a viscosity of about 200,000 cps at a shear rate of 0.1/second.
3. The pharmaceutical composition of claim 1 , wherein the triamcinolone is present in a plurality of particles and the plurality of particles remain substantially uniformly suspended in the composition for at least 1 year without requiring resuspension processing.