METHODS OF DECREASING SEBUM PRODUCTION IN THE SKIN
Provided herein are methods of using gaseous nitric oxide and/or at least one nitric oxide source to or decrease sebum production in the skin of a subject. In some embodiments, the nitric oxide source includes small molecule and/or macromolecular NO-releasing compounds,
1 . A method of decreasing sebum production in skin of a subject comprising applying nitric oxide and/or at least one nitric oxide source to the skin in an amount sufficient to decrease sebum production.
2 . The method of claim 1 , wherein the sebum production in the skin is decreased by applying gaseous nitric oxide to the skin of the subject.
3 . The method of claim 1 , wherein the sebum production in the skin is decreased by applying at least one nitric oxide source to the skin of the subject.
4 . The method of claim 3 , wherein the at least one nitric oxide source comprises a nitric oxide (NO)-releasing compound.
5 . The method of claim 4 , wherein the NO-releasing compound comprises a small molecule NO-releasing compound.
6 . The method of claim 4 , wherein the NO-releasing compound comprises a macromolecular NO-releasing compound.
7 . The method of claim 6 , wherein the macromolecular NO-releasing compound comprises N-diazeniumdiolate-functionalized macromolecules.
8 . The method of claim 7 , wherein the N-diazeniumdiolate-functionalized macromolecules comprise N-diazeniumdiolate co-condensed polysiloxane macromolecules.
9 . The method of claim 6 , wherein the macromolecular NO-releasing compound comprises nitrosothiol-functionalized macromolecules.
10 . The method of claim 4 , wherein the NO-releasing compound is present in a pharmaceutically acceptable composition.
11 . The method of claim 10 , wherein the pharmaceutically acceptable composition comprises at least one other therapeutic agent.
12 . The method of claim 1 , wherein the nitric oxide is applied at a concentration that is toxic production sites,
13 . The method of claim 1 , wherein the nitric oxide is applied at a concentration that is not toxic to sebum production sites.
14 . The method of claim 1 , wherein the nitric oxide is applied at a concentration that is preferentially toxic to sebum production sites over keratinocytes.
15 . A method of decreasing sebum production in skin of a subject comprising systemically applying nitric oxide and/or at least one nitric oxide source to the subject in an amount sufficient to decrease sebum production in the skin.