Passive spiral micromixer and its applications
A micro-mixer and use thereof for synthesis of barium sulfate particles is disclosed. The micro-mixer includes feeding tubes, reservoirs, a mixing channel, a buffer reservoir and a sampling tube. The mixing channel is made of hydrophobic materials and processed into a spiral structure, in which baffles are set in interval arrangement at both sides of the channel wall. The types of the baffles include leaning-forward baffles, vertical baffles and leaning-backward baffles. Setting the baffles helps produce local secondary flow in the mixer, which enhances fluids mixing process. The micro-mixer is suitable to rapid reactions or precipitation processes, whose reaction time is much less than mixing time, and has broad application prospects in many fields involving mixing reaction such as pharmaceutical and chemistry industry.
1. A passive spiral micro-mixer with baffles comprising at least two inlet fluid reservoirs, at least two inlet channels, a spiral mixing channel, baffles and a buffer reservoir,
wherein the inlet fluid reservoir is connected with a feeding tube on one end and an inlet channel on another end, and the other end of the inlet channel is connected with the spiral mixing channel; the inlet angle at the intersection between two inlet channels is α, which interchange at the spiral mixing channel;
the baffles are set in interval arrangement at both sides of the spiral mixing channel wall, and they are arranged more intensively at entrance section than those at fully developed section; the angle between the baffle and the spiral mixing channel wall is β;
the outlet end of the spiral mixing channel is connected with the buffer reservoir, and the sample in the buffer reservoir is collected through an outlet tube.
2. The passive spiral micro-mixer according to claim 1 , wherein the micro-mixer is made of hydrophobic material.
3. The passive spiral micro-mixer according to claim 1 , wherein the inlet angle at the intersection between two inlet channels α is 60°-300°.
4. The passive spiral micro-mixer according to claim 1 , wherein the micro-mixer has spiral geometry, wherein the radius of inner circle is 1-3 cm while the radius of outer circle is 6-8 cm; cylinder number is 3-10; the cross-section of the spiral mixing channel is rectangular; the width of the mixing channel is 0.8-1 mm; and the ratio of width to depth is 1/10.
5. The passive spiral micro-mixer according to claim 1 , wherein the baffles in the micro-mixer are arranged more intensively at the entrance section than those at the fully developed section; at the entrance section, the baffles are arranged every 15° of the central angle, at fully developed section the baffles are arranged every 45° of the central angle, and the changes is in the step of 15°.
6. The passive spiral micro-mixer according to claim 1 , wherein the height of baffles in the micro-mixer is identical with the depth of the mixing channel, and the length of the baffles is ⅓-½ of the channel width.
7. The passive spiral micro-mixer according to claim 1 , wherein the baffles are leaning-forward when β<90°, leaning-backward when β>90°, and when β=90° vertical baffles are obtained.
8. A method of synthesis of barium sulfate particles in the passive spiral micro-mixer according to claim 1 comprises:
Na 2 SO 4 and BaCl 2 solutions at identical concentration ranging from 1 mol/L to 2.5 mol/L are fed into the micro-mixer at the same volumetric flow rate which ranges from 1 mL/min to 5 mL/min and mixed;
the mixture collected from the outlet of the micro-mixer is firstly washed using ethanol and then dried at 100° C. for 24 hours, and give barium sulfate particles with d 43 ranging from 100 nm to 500 nm.
9. The passive spiral micro-mixer according to claim 2 , wherein the hydrophobic material is polydimethylsiloxane or polymethyl methacrylate.