Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a topical composition is provided, which can be formulated as a homogenous mixture, such as a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension or applied on a carrier material, such as a bandage, gauze, foam, sponge, hydrogel, hydrocolloid, hydrofiber, occlusive dressing, adhesive composition or scaffold. Methods for producing such a topical composition and carrier material with the topical composition applied thereto are also disclosed.
1. A method for promoting wound healing comprising contacting a wound site with a topical composition comprising an effective amount of a lipoic acid derivative and an effective amount of a sacrificial proteolytic enzyme substrate, wherein the topical composition is applied to a wound dressing capable of distributing reduced pressure to the wound site.
2. The method of claim 1 , wherein the effective amount of a lipoic acid derivative and the effective amount of a sacrificial proteolytic enzyme substrate function to reduce inflammation and promote wound healing.
3. The method of claim 1 , wherein the lipoic acid derivative and the sacrificial proteolytic enzyme substrate form a homogenous mixture.
4. The method of claim 1 , wherein the sacrificial proteolytic enzyme substrate comprises gelatin.
5. The method of claim 1 , wherein the lipoic acid derivative comprises the structure:
wherein n1 and n2 are, independently, C 1 -C 10 alkyl; and
R 1 is H, C 1 -C 10 alkyl, C 6 -C 14 aryl, an alkyl ammonium or a protonated amino acid.
6. The method of claim 1 , wherein the lipoic acid derivative is a dihydrolipoic acid comprising the structure:
wherein n1 and n2 are, independently, C 1 -C 10 alkyl;
R 1 is H, C 1 -C 10 alkyl, C 6 -C 14 aryl, an alkyl ammonium or a protonated amino acid; and
R 2 is H, C 1 -C 10 alkyl or C 6 -C 14 aryl.
7. The method of claim 1 , wherein the lipoic acid derivative is provided as a pharmaceutically acceptable salt.
8. The method of claim 1 , wherein the lipoic acid derivative is alpha-lipoic acid or sodium lipoate.
9. The method of claim 1 , wherein the topical composition comprises 0.1% to 5% or 0.01% to 10% w/w lipoic acid derivative.
10. The method of claim 1 , wherein the topical composition comprises 0.1% to 25% w/w of a sacrificial proteolytic enzyme substrate.
11. The method of claim 1 , wherein the topical composition further comprises one or more of an antimicrobial agent, a growth factor, a proteinase inhibitor, a chelating agent or a preservative.
12. The method of claim 11 , wherein the antimicrobial agent is at least one of non-ionic silver, polyhexamethylene biguanide, chlorhexidine, benzalconium chloride or triclosan.
13. The method of claim 11 , wherein the chelating agent is ethylenediaminetetraacetic acid.
14. The method of claim 1 , wherein the topical composition is in the form of a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension.