TEC family kinase inhibitor adjuvant therapy
View Patent ↗Described herein are methods and compositions comprising a covalent TEC family kinase inhibitor for use in adjuvant therapy, including adjuvant cancer therapy, vaccination and treatment of immune disorders and pathogenic infections.
1. A method of treating a subject having adult T-cell leukemia/lymphoma (ATLL) following treatment with a first anticancer therapy, comprising
administering to the subject an effective amount of ibrutinib to treat the adult T-cell leukemia/lymphoma (ATLL), after the discontinuation of the first anticancer therapy, and wherein the first anticancer therapy does not comprise administration of ibrutinib.
2. The method of claim 1 , wherein the first anticancer therapy comprises administration of a chemotherapeutic agent, a biologic agent, radiation therapy, bone marrow transplant, surgery, or a combination thereof.
3. The method of claim 1 , wherein the first anticancer therapy is a chemotherapeutic agent or biologic agent selected from among CHOP (cyclophosphamide, hydroxydoxorubicin, vincristine, and prednisone), EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, hydroxydoxorubicin), Hyper-CVAD (cyclophosphamide, vincristine, hydroxydoxorubicin, dexamethasone), ICE (ifosfamide, carboplatin, etoposide), DHAP (high-dose cytarabine [ara-C], dexamethasone, cisplatin), ESHAP (etoposide, methylprednisolone, cytarabine [ara-C], cisplatin), anthracycline-based chemotherapy, a histone deacetylase (HDAC) inhibitor, a proteasome inhibitor, an immunomodulatory agent, an antibody, a nucleoside analogs, a PI3K inhibitor, an IAP inhibitor, an mTOR inhibitor, a radioimmunotherapeutic, a DNA damaging agent, a protein kinase inhibitor, a hedgehog inhibitor, an Hsp90 inhibitor, a telomerase inhibitor, a Jak1/2inhibitor, a protease inhibitor, an IRAK inhibitor, a PKC inhibitor, a PARP inhibitor, a CYP3A4inhibitor, an alkylating agent, an anti metabolite, a plant alkaloid, a terpenoid, a cytotoxin, a topoisomerase inhibitor, or a combination thereof.
4. The method of claim 1 , wherein ibrutinib is administered at a dosage of about 40 mg/day to about 1000 mg/day.
5. The method of claim 1 , wherein the subject has a high risk of cancer recurrence prior to administration of ibrutinib.
6. The method of claim 1 , wherein the administering of ibrutinib is initiated less than 3 weeks after discontinuation of the first anticancer therapy.