Substituted 6,5-fused bicyclic heteroaryl compounds
View Patent ↗The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
1. A method of treating lymphoma comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (IIIa) or a pharmaceutically acceptable salt thereof:
wherein
each of R 1 , R 3 , R 8 , and R 11 is H;
each of R 2 and R 4 is methyl;
R 6 is phenyl or pyridinyl, each substituted with one -Q 2 -T 2 , in which Q 2 is a methyl linker and T 2 is morpholinyl, and R 6 is optionally further substituted with methyl or Cl; and
R 7 is cyclopentyl or isopropyl.
2. The method of claim 1 , wherein R 6 is phenyl substituted with one -Q 1 -T 1 .
3. The method of claim 2 , wherein R 7 is cyclopentyl.
4. The method of claim 1 wherein the lymphoma is selected from the group consisting of B-cell lymphoma, diffuse large B-cell lymphoma, germinal center B cell-like lymphoma, cutaneous T-cell lymphoma, AIDS-related lymphoma, nervous system lymphoma, follicular lymphoma, and non-Hodgkin lymphoma.
5. The method of claim 1 wherein the lymphoma is B-cell lymphoma.
6. The method of claim 1 , wherein R 6 is pyridinyl substituted with one -Q 2 -T 2 .
7. The method of claim 6 , wherein R 7 is cyclopentyl.
8. The method of claim 1 , wherein the compound is selected from
and pharmaceutically acceptable salts thereof.
9. The method of claim 1 , wherein the compound is
10. The method of claim 1 , wherein the compound is a pharmaceutically acceptable salt of