COMPOSITION OF AQUEOUS BUFFER SOLUTION FOR THE TREATMENT OF CELLULAR ENVIRONMENT AND ION CHANNELS AND METHODS FOR USING SAME
This invention relates to a buffering composition for the topical or internal treatment of animal tissues to buffer and normalize the pH of the cellular environment while also affecting specific cellular membrane ion channels as a method to affect inflammation, proteases, reactive oxygen species and free radicals, the composition containing a pharmaceutically-effective concentration of an acid and its base salt, where the counterions of the base salt are potassium and at least one of cesium and rubidium, or all three.
1 . A method comprising:
applying a buffering composition containing a pharmaceutically-effective concentration of an acid and a complementary base salt of the acid, counterions of the complementary base salt including potassium and at least one of cesium and rubidium, to an area of a body exhibiting inflammation; and
monitoring an effect of the buffering composition on the area of the body to adjust a subsequent application of the buffering composition.
2 . The method of claim 1 , wherein the counterions of the complementary base salt include all of potassium, cesium and rubidium.
3 . The method of claim 1 , wherein the inflammation is associated with psoriasis.
4 . The method of claim 1 , wherein the inflammation is associated with rosacea.
5 . The method of claim 1 , wherein the pharmaceutically-effective concentration of the acid and the complementary base salt is less than 1,000 mmolar.
6 . The method of claim 1 , wherein the acid is ascorbic acid.
7 . The method of claim 1 , wherein the acid is citric acid.
8 . The method of claim 1 , wherein the acid is hyaluronic acid.
9 . The method of claim 1 , wherein the acid is lactic acid.
10 . The method of claim 1 , wherein the acid is a mixture of citric and hyaluronic acids.