Ectoparasiticidal methods and formulations
View Patent ↗Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram, or a pharmaceutically acceptable salt thereof.
1. A topical liquid pharmaceutical formulation comprising about 8-14 wt/wt % of spinetoram, or a pharmaceutically acceptable salt thereof, about 15-20 wt/wt % of benzyl alcohol, and about 65-75 wt/wt % of propylene carbonate, and optionally one or more pharmaceutically acceptable carriers.
2. The formulation of claim 1 , wherein said spinetoram, or a pharmaceutically acceptable salt thereof, is present in an amount of about 70-100 milligrams.
3. The formulation of claim 2 , wherein said spinetoram, or a pharmaceutically acceptable salt thereof, is present in an amount of about 85-95 milligrams.
4. The formulation of claim 3 , wherein said spinetoram, or a pharmaceutically acceptable salt thereof, is present in an amount of about 91 milligrams.
5. The formulation of claim 1 , wherein said spinetoram, or a pharmaceutically acceptable salt thereof, is present in an amount of about 10-12 wt/wt % of the formulation.
6. The formulation of claim 5 , wherein said spinetoram, or a pharmaceutically acceptable salt thereof, is present in an amount of about 11.2 wt/wt %.
7. The formulation of claim 1 , wherein said benzyl alcohol is present in an amount of about 17-19 wt/wt %.
8. The formulation of claim 7 , wherein said benzyl alcohol is present in an amount of about 18 wt/wt %.
9. The formulation of claim 1 , wherein said propylene carbonate is present in an amount of about 67-71 wt/wt %.
10. The formulation of claim 9 , wherein said propylene carbonate is present in an amount of about 69 wt/wt %.
11. The formulation of claim 1 , wherein said pharmaceutical formulation has a volume of about 0.7 ml.
12. The formulation of claim 1 , wherein said formulation is unit dosage form.
13. A topical liquid pharmaceutical formulation comprising about 11.2 wt/wt % of spinetoram, about 18 wt/wt % of benzyl alcohol, and about 69 wt/wt % of propylene carbonate, and optionally one or more pharmaceutically acceptable carriers.
14. The formulation of claim 13 , wherein said formulation has a volume of about 0.7 ml.
15. The formulation of claim 13 , wherein said formulation is in unit dosage form.
16. A method of controlling an ectoparasite infestation on a cat which comprises topically administering a formulation of claim 1 on said cat.
17. The method of claim 16 , wherein said administration is spot-on, plunge or spray dipping, jetting with a hand held spray or in a race, or as a back-line spray or pour-on.
18. The method of claim 16 , wherein said administration is carried out no more than biweekly.
19. The method of claim 18 , wherein said administration is carried out no more than monthly.
20. The method of claim 16 , wherein said ectoparasite is Ctenocephalides felis.
21. A method of controlling an ectoparasite infestation on a cat which comprises topically administering a formulation of claim 13 on said cat.
22. The method of claim 21 , wherein said administration is spot-on, plunge or spray dipping, jetting with a hand held spray or in a race, or as a back-line spray or pour-on.
23. The method of claim 21 , wherein said administration is carried out no more than biweekly.
24. The method of claim 23 , wherein said administration is carried out no more than monthly.
25. The method of claim 21 , wherein said ectoparasite is Ctenocephalides felis.