Granted Patent B2

US 9,139,517 · App. 14/076,406 · Granted Sep 22, 2015

Abstract

Claims (16)

1. Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate which exhibits characteristic scattering angles (2Θ) at least at 4.33°±0.2°, 4.76°±0.2°, 11.06°±0.2° and 11.61°±0.2° in an X-ray powder diffractogram measured using Cu—K α radiation.

2. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , comprising characteristic scattering angles (2Θ) at least at 4.33°±0.2°, 4.76°±0.2°, 5.83°±0.2°, 9.07°±0.2°, 9.46°±0.2°, 10.54°±0.2°, 11.06°±0.2°, 11.61°±0.2°, 12.94°±0.2°, 17.46°±0.2°, 17.84°±0.2°, 18.01°±0.2°, 19.36°±0.2°, 20.01°±0.2° and 21.26°±0.2° in an X-ray powder diffractogram measured using Cu—K α radiation.

3. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , comprising characteristic scattering angles (2Θ) at least at 4.33°±0.2°, 4.76°±0.2°, 5.83°±0.2°, 6.93°±0.2°, 9.07°±0.2°, 9.46°±0.2°, 10.54°±0.2°, 11.06°±0.2°, 11.61°±0.2°, 12.94°±0.2°, 15.25°±0.2°, 16.55°±0.2°, 17.46°±0.2°, 17.84°±0.2°, 18.01°±0.2°, 18.41°±0.2°, 18.69°±0.2°, 18.93°±0.2°, 19.36°±0.2°, 20.01°±0.2°, 20.46°±0.2°, 21.26°±0.2°, 21.75°±0.2°, 22.19°±0.2°, 22.56°±0.2°, 23.35°±0.2°, 23.85°±0.2°, 24.84°±0.2°, 25.96°±0.2°, 26.78°±0.2°, 27.29°±0.2°, 28.69°±0.2°, 29.39°±0.2°, 31.22°±0.2°, 32.35°±0.2°, 33.47°±0.2°, 34.62°±0.2° and 36.08°±0.2° in an X-ray powder diffractogram measured using Cu—K α radiation.

4. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which exhibits a strong characteristic Raman spectrum band at 119 cm −1 .

5. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which exhibits characteristic Raman spectrum bands at least at 119 cm −1 and 85 cm −1 .

6. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which exhibits characteristic Raman spectrum bands at least at 1599 cm −1 , 1447 cm −1 , 798 cm −1 , 119 cm −1 and 85 cm −1 .

7. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which exhibits characteristic Raman spectrum bands at least at 1747 cm −1 , 1599 cm −1 , 1447 cm −1 , 1412 cm −1 , 1335 cm −1 , 1203 cm −1 , 1092 cm −1 , 954 cm −1 , 868 cm −1 , 798 cm −1 , 637 cm −1 , 401 cm −1 , 348 cm −1 , 317 cm −1 , 244 cm −1 , 119 cm −1 and 85 cm −1 .

8. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which has a critical water activity of less than or equal to about 0.75±0.05.

9. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which undergoes thermal decomposition at a temperature ranging from about 170° C. to about 190° C. using a thermogravimetric analyzer coupled with a Fourier-transform infrared spectrometer at a scan rate of about 10 K/min.

10. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which undergoes a melt/phase transition at a temperature ranging from about 120° C. to about 140° C. using differential scanning calorimetry at a heating rate of 20 K/min.

11. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 10 , wherein the melt/phase transition occurs at about 131° C. using differential scanning calorimetry at a heating rate of 20 K/min.

12. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 10 , wherein the melt/phase transition occurs at about 131.3° C. using differential scanning calorimetry at a heating rate of 20 K/min.

13. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which contains less than about 0.05 wt % water at 50% relative humidity as measured by dynamic vapor sorption.

14. The crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 , which contains less than about 0.1 wt % water at 95% relative humidity as measured by dynamic vapor sorption.

15. A pharmaceutical composition comprising the crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate of claim 1 and a pharmaceutically acceptable vehicle.

16. The pharmaceutical composition of claim 15 , wherein the pharmaceutical composition is a sustained release oral dosage formulation.

Assignments (8)