Devices and methods for endoluminal delivery of either fluid or energy for denervation
Described herein are methods and devices for selectively applying either fluids (e.g., anesthetics, nerve-blockers, etc.) or energy, such as radiofrequency or ultrasound energy, to a target tissue from within a blood vessel while minimizing the amount of fluid or energy applied to non-target tissue. The catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter. In addition, catheters can include energy applying features for delivering energy to the target tissue.
1. A catheter device, comprising:
an elongate body having a distal end and a proximal end;
a first inflatable holdfast positioned along the elongate body adjacent the distal end of the elongate body;
a second inflatable holdfast positioned along the elongate body adjacent the first inflatable holdfast, the first inflatable holdfast and the second inflatable holdfast being configured to inflate and anchor the catheter device within a carotid artery; and
an energy providing feature secured to the elongate body at a first location between the first and second inflatable holdfasts, the energy providing feature configured to deliver energy from the first location,
wherein the second inflatable holdfast is positioned a distance from the first inflatable holdfast, the distance allowing the energy providing feature to be securely positioned adjacent a carotid body when the first inflatable holdfast and the second inflatable holdfast are inflated within a carotid artery thereby allowing the energy providing feature to deliver energy from the first location to a carotid body.
2. The catheter device of claim 1 , wherein the energy delivered to the target area is radiofrequency energy.
3. The catheter device of claim 1 , wherein the energy delivered to the target area is ultrasound energy.
4. The catheter device of claim 1 , wherein the energy providing feature includes an electrode.
5. The catheter device of claim 1 , wherein the energy providing feature includes a transducer and an acoustic element.
6. The catheter device of claim 1 , wherein the elongate body has a length suitable for treatment of a carotid body via a transcervical approach.
7. The catheter device of claim 6 , wherein the length of the elongate body is within a range of approximately 40 centimeters to 80 centimeters.
8. The catheter device of claim 1 , further comprising:
a passageway extending along a part of the elongate body, the passageway including a distal end positioned at a second location between the first inflatable holdfast and the second inflatable holdfast and
an injector slidably engaged with the passageway and configured to extend from the elongate body at the second location and into tissue.
9. A method, comprising:
inserting at least a part of a catheter device into a vessel body, wherein the catheter device includes an elongate body having a distal end and a proximal end, a first inflatable holdfast positioned along the elongate body adjacent the distal end of the elongate body, a second inflatable holdfast positioned along the elongate body adjacent the first inflatable holdfast, wherein the first inflatable holdfast and the second inflatable holdfast are configured to inflate and anchor the catheter device within a carotid artery, and an energy providing feature secured to the elongate body at a first location between the first inflatable holdfast and the second inflatable holdfast, the energy providing feature configured to deliver energy from the first location, wherein the second inflatable holdfast is positioned a distance from the first inflatable holdfast, the distance allowing the energy providing feature to be securely positioned adjacent a carotid body when the first inflatable holdfast and the second inflatable holdfast are inflated within a carotid artery thereby allowing the energy providing feature to deliver energy from the first location to a carotid body;
positioning the energy providing feature of the catheter device within a carotid artery and adjacent a carotid body;
inflating the first inflatable holdfast and the second inflatable holdfast thereby anchoring the catheter device within the carotid artery; and
delivering energy from the energy feature to the carotid body.
10. The method of claim 9 , wherein the energy delivered to the target area is at least one of radiofrequency energy and ultrasound energy.
11. The method of claim 9 , wherein the energy providing feature includes at least one of an electrode, a transducer and an acoustic element.
12. The method of claim 9 , wherein the catheter device further includes an extendable injector configured to extend from the elongate body and into the target area for delivering a fluid that causes denervation of at least one nerve.
13. The method of claim 9 , wherein the elongate body has a length suitable for treatment of a carotid body via a transcervical approach.
14. The method of claim 13 , wherein the length of the elongate body is within a range of approximately 40 centimeters to 80 centimeters.
15. The catheter device of claim 8 , wherein the first inflatable holdfast and the second inflatable holdfast are asymmetrically positioned along the elongate body thereby positioning at least one of the energy providing feature and the distal end of the passageway against an inner wall of a carotid artery when the first inflatable holdfast and the second inflatable holdfast are inflated.