Flow promoting ocular implant
View Patent ↗Disclosed are devices, methods and systems for treatment of eye disease, including open angle glaucoma and narrow angle glaucoma. Implants are described herein that create a directed flow field, such as between the anterior chamber and either the supraciliary space or suprachoroidal space. In addition, the implant can include a variety of features, including extruded features, such as rings and pegs, which can assist in preventing ocular tissue from collapsing onto the implant and occluding fluid pathways.
1. An ocular implant system for implanting an implant in an eye comprising:
an elongate tubular body comprising a proximal end, a distal end and an inner lumen extending at least partway between the proximal end and the distal end, the tubular body having a plurality of holes positioned along the length of the tubular body;
a plurality of fenestrations extending through an outer surface of the tubular body and intersecting with the inner lumen; and
a plurality of extruded features wherein at least one of the plurality of extruded features extends from the outer surface of the tubular body, and wherein the plurality of extruded features includes a plurality of extruded rings, and wherein each fenestration is positioned immediately adjacent an extruded ring such that each extruded ring immediately adjacent a fenestration tents eye tissue around each fenestration in a manner that results in fluid flow through at least one of the fenestrations when the elongate tubular body is implanted in an eye, and wherein the plurality of extruded rings includes at least one extruded ring positioned at a distal end of the elongate tubular body and at least one extruded ring positioned at a proximal end of the elongate tubular body;
a delivery device configured to insert the tubular body into the eye, the delivery device including:
a handle;
a guidewire that inserts longitudinally through the inner lumen of the tubular body, the guidewire having an interior lumen for passage of fluid and also having a plurality of openings through which fluid can exit the interior lumen of the guidewire;
a sheath positioned axially over the guidewire and positioned proximal of the tubular body when the tubular body is positioned on the guidewire.
2. The implant of claim 1 wherein the implant is made out of a medical grade material, including at least one of a stainless steel, polyimide, various plastics, or any number of shape memory alloys, including nitinol, and shape memory polymers.
3. The implant of claim 1 wherein at least one of the plurality of extruded features comprises a large proximal ring.
4. The implant of claim 1 wherein the plurality of fenestrations vary in at least one of size and shape.
5. The implant of claim 4 wherein the size of the fenestrations increase along a length of the implant in a distal direction.
6. The implant of claim 4 wherein the fenestrations increase in number along a length of the implant in a distal direction.
7. The implant of claim 1 wherein the plurality of rings vary in at least one of size and shape.
8. The implant of claim 7 wherein the extruded features increase in size along a length of the implant in a distal direction.
9. The implant of claim 1 wherein the implant includes at least one of a beveled proximal end and a beveled distal end.
10. The implant of claim 1 wherein at least one of the proximal end or the distal end includes at least one of a chamfered edge and radiused edge.
11. The implant of claim 1 wherein the implant is at least one of coated with a drug and comprised of a polymer combined with a drug.
12. A method of implanting an implant in an eye, comprising;
securing an implant to a delivery device configured to insert the implant into the eye, the implant comprising
an elongate tubular body including a proximal end, a distal end and an inner lumen extending at least partway between the proximal end and the distal end;
a plurality of fenestrations extending through an outer surface of the tubular body and intersecting with the inner lumen; and
an a plurality of extruded features extending from the outer surface of the tubular body, and wherein the plurality of extruded features includes a plurality of extruded rings, and wherein each fenestration is positioned immediately adjacent an extruded ring such that each extruded ring immediately adjacent a fenestration tents eye tissue around each fenestration in a manner that results in fluid flow through at least one of the fenestrations when the elongate tubular body is implanted in an eye;
the delivery device comprising:
a handle;
a guidewire that inserts longitudinally through the inner lumen of the tubular body, the guidewire having an interior lumen for passage of fluid and also having a plurality of openings through which fluid can exit the interior lumen of the guidewire;
a sheath positioned axially over the guidewire and positioned proximal of the tubular body when the tubular body is positioned on the guidewire; and
inserting the implant into the eye such that each extruded ring tents eye tissue around each of the corresponding fenestrations when the elongate tubular body is implanted in an eye in a manner that results in fluid flow through at least one of the fenestrations.