IP Library Granted Patent US 9,434,754
Granted Patent B2
US 9,434,754 · App. 14/079,018 · Granted Sep 6, 2016

Use of an adrenal hormone-modifying agent

Inventors: Qi-Ying Hu (Needham, MA); Gary Michael Ksander (Amherst, MA); Erik Meredith (Hudson, MA); Lauren G Monovich (Belmont, MA); Julien Papillon (Somerville, MA); Christoph Schumacher (Bettingen, CH)
Assignee: Novartis AG
C07F9/6506A61K31/4188A61K31/55C07D487/04
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Quick Facts
Patent No.
US 9,434,754
App. No.
14/079,018
Granted
Sep 6, 2016
Kind
B2
Abstract

The present invention relates to a method of treating a disease or disorder characterized by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I): wherein n is 1 or 3; R is hydrogen or —C(O)N(R a )(R b ) wherein R a and R b are independently —(C 1 -C 4 ) alkyl, or —(C 1 -C 4 ) alkyl-(C 5 -C 7 ) aryl, wherein each of R a and R b is optionally substituted by —(C 1 -C 4 ) alkoxy; R 1 , R 2 , and R 3 , are independently hydrogen, halogen, cyano or —(C 6 -C 10 ) aryl, wherein said —(C 6 -C 10 ) aryl is optionally substituted by halogen, with the proviso that no more than one of R 1 , R 2 , and R 3 is hydrogen; and R 4 and R 5 are hydrogen; or a pharmaceutically acceptable salt thereof.

Claims (2)

1. A compound which is 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile dihydrogen phosphate;

or a pharmaceutically acceptable salt thereof.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2020
From: NOVARTIS AG
To: RECORDATI AG
Reel/Frame 051945/0630 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 14, 2020
From: HU, QIIYING; KSANDER, GARY MICHAEL; MEREDITH, ERIK; MONOVICH, LAUREN G; PAPILLON, JULIEN; SCHUMACHER, CHRISTOPH
To: NOVARTIS AG
Reel/Frame 051821/0789 →
Continuity (3)
Continuation 13521548
Provisional Application 61294980 · Jan 14, 2010
Related Publication 20140171392A1 · Jun 19, 2014