IP Library › Granted Patent US 9,549,926
Granted Patent B2
US 9,549,926 · App. 14/079,548 · Granted Jan 24, 2017

Compositions and methods of treating pulmonary hypertension

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Quick Facts
Patent No.
US 9,549,926
App. No.
14/079,548
Granted
Jan 24, 2017
Kind
B2
Abstract

Provided are formulations comprising therapeutically effective amounts of ambrisentan or a pharmaceutically acceptable salt thereof and tadalafil or a pharmaceutically acceptable salt thereof and methods of treating and/or preventing pulmonary hypertension by administration of the formulations.

Claims (6)

1. A method for treating pulmonary arterial hypertension in a human patient in need thereof, comprising co-administering to the patient a therapeutic amount of ambrisentan and a therapeutically effective amount of tadalafil, wherein the weight ratio of the ambrisentan to the tadalafil is about 1:2 or about 1:3.

2. The method of claim 1 , wherein the weight ratio of the ambrisentan to the tadalafil is about 1:2.

3. The method of claim 1 , wherein the ambrisentan and the tadalafil are administered in a sequential manner.

4. The method of claim 1 , wherein the ambrisentan and the tadalafil are administered at the same time.

5. The method of claim 1 , wherein the ambrisentan and the tadalafil are administered orally or parenterally.

6. The method of claim 1 , wherein the weight ratio of the ambrisentan to the tadalafil is about 1:3.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 31, 2015
From: BELARDINELLI, LUIZ; GILLIES, HUNTER CAMPBELL; LIANG, FAQUAN; YANG, SUYA; SHRYOCK, JOHN
To: GILEAD SCIENCES, INC.
Reel/Frame 035299/0042 →