ROTATIONAL SPUN MATERIAL COVERED MEDICAL APPLIANCES AND METHODS OF MANUFACTURE
A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.
1 . A method of constructing a medical appliance, comprising:
dissolving polyethylene oxide (PEO) in water to form a gel;
mixing a polytetrafluoroethylene (PTFE) aqueous dispersion with the gel to form a PTFE/PEO solution, wherein the ratio of PEO to PTFE corresponds to a ratio between about 0.04 g and about 0.12 g of PEO per ml of 60 wt % PTFE dispersion; and
rotational spinning the PTFE/PEO solution to form a portion of a medical appliance.
2 . The method of claim 1 , wherein the ratio of PEO to PTFE is between about 0.06 g to about 0.08 g of PEO per ml of 60 wt % PTFE dispersion.
3 . The method of claim 2 , wherein the ratio of PEO to PTFE is about 0.07 g of PEO per ml of 60 wt % PTFE dispersion.
4 . The method of claim 1 , wherein mixing the PTFE dispersion with the gel comprises mixing in a non-agitating jar roller.
5 . The method of claim 4 , wherein mixing the PTFE dispersion with the gel comprises mixing in a non-agitating jar roller for at least 24 hours.
6 . The method of claim 1 , wherein the gel is mixed with a 60 wt % PTFE dispersion.
7 . The method of claim 1 , further comprising filtering PTFE/PEO solution to remove particles.
8 . The method of claim 1 , wherein the PTFE/PEO solution reaches homogeneity.
9 . The method of claim 1 , wherein rotational spinning the PTFE/PEO solution comprises rotational spinning the PTFE/PEO solution onto a mandrel.
10 . The method of claim 1 , further comprising sintering the rotational spun medical device.
11 . The method of claim 1 , wherein dissolving the PEO in water comprises dissolving PEO in water at a ratio of about 2.86 ml of water per gram of PEO.
12 . A method of preparing a rotational spinning solution, comprising:
dissolving polyethylene oxide (PEO) in water to form a gel; and
mixing a polytetrafluoroethylene (PTFE) aqueous dispersion with the gel to form a PTFE/PEO solution, wherein the ratio of PEO to PTFE corresponds to a ratio between about 0.04 g and about 0.12 g of PEO per ml of 60 wt % PTFE dispersion.
13 . The method of claim 12 , wherein the ratio of PEO to PTFE is between about 0.06 g to about 0.08 g of PEO per ml of 60 wt % PTFE dispersion.
14 . The method of claim 13 , wherein the ratio of PEO to PTFE is about 0.07 g of PEO per ml of 60 wt % PTFE dispersion.
15 . The method of claim 12 , wherein mixing the PTFE dispersion with the gel comprises mixing in a non-agitating jar roller.
16 . The method of claim 15 , wherein mixing the PTFE dispersion with the gel comprises mixing in a non-agitating jar roller for at least 24 hours.
17 . The method of claim 12 , wherein the gel is mixed with a 60 wt % PTFE dispersion.
18 . The method of claim 12 , further comprising filtering PTFE/PEO solution to remove particles.
19 . The method of claim 12 , wherein the PTFE/PEO solution reaches homogeneity.
20 . The method of claim 12 , wherein dissolving the PEO in water comprises dissolving PEO in water at a ratio of about 2.86 ml of water per gram of PEO.