Bulking agents

1. A method for bulking mammalian tissue comprising the steps of:

introducing a bulking agent to the mammalian tissue, the bulking agent comprising: a carrier, and a plurality of substantially spherical polyvinyl alcohol particles dispersed within the carrier, the substantially spherical polyvinyl alcohol particles comprising surface pores covering up to 80% of the total surface area of the particles and the carrier aiding delivery of the substantially spherical polyvinyl alcohol particles to a site to be bulked; and

coapting the mammalian tissue with the substantially spherical polyvinyl alcohol particles.

2. The method of claim 1 further comprising the step of viewing the tissue to be bulked during the introducing step.

3. The method of claim 1 wherein the bulking agent comprises a volume from about 1 ml to about 30 ml.

4. The method of claim 1 wherein at least some of the substantially spherical polyvinyl alcohol particles are sized from about 40 microns to about 1500 microns in diameter.

5. The method of claim 1 wherein the substantially spherical polyvinyl alcohol particles comprise surface pores within a range of 4 to 50 microns.

6. The method of claim 1 wherein the substantially spherical polyvinyl alcohol particles comprise surface pores within a range of 5 to 30 microns.

7. The method of claim 1 wherein the substantially spherical polyvinyl alcohol particles are sized from 150 microns to 1100 microns in diameter.

8. The method of claim 1 wherein the substantially spherical polyvinyl alcohol particles are sized from 500 microns to 900 microns in diameter.

9. The method of claim 1 wherein the bulking agent is introduced into the mammalian tissue by through a needle.

10. The method of claim 9 wherein the needle is a 16 to 24 gauge needle.

11. The method of claim 9 wherein the needle is an 18 to 22 gauge needle.

12. The method of claim 1 wherein the substantially spherical polyvinyl alcohol particles comprise alginate.

13. The method of claim 1 wherein the bulking agent is delivered transurethrally to a urethra with a cystoscope comprising a light transmitting element, a working channel and a viewing element.

14. The method of claim 13 wherein the bulking agent is delivered by an elongate needle inserted through the working channel of the cystoscope.

15. The method of claim 1 wherein the bulking agent is injected around an enlarged lumen of a urethra.

16. The method of claim 1 wherein the bulking agent comprises a contrast agent.

17. A method for bulking mammalian tissue comprising:

inserting an inflation device within a portion of a mammal;

inflating the inflation device, thereby creating a void in the tissue; and

at least partially filling the void with a bulking agent that comprises a carrier and a plurality of polymeric particles dispersed within the carrier, wherein the plurality of polymeric particles comprise surface pores covering up to 80% of the total surface area of the particles.

18. The method of claim 17 , wherein the polymeric particles are sized in a range of about 40 microns to about 1500 microns in diameter.

19. The method of claim 18 , wherein the polymeric particles comprise polyvinyl alcohol particles having surface pores.

20. The method of claim 12 , wherein the substantially spherical polyvinyl alcohol particles are made by a process comprising:

forming substantially spherical droplets comprising polyvinyl alcohol and alginate;

crosslinking the polyvinyl alcohol in the substantially spherical droplets; and

subsequently removing alginate from an outer surface of the substantially spherical droplets to form substantially spherical particles that are substantially all polyvinyl alcohol.