Closed loop control system based on a non-invasive continuous sensor
View Patent ↗Methods and systems for controlling analyte levels are described. An example method may include receiving a sensor measurement relating to an eye-mountable device. The method also may include determining an analyte concentration based on the one or more sensor measurements, and comparing the analyte concentration to a target analyte concentration. Based on the comparing, the method further may include providing instructions to a drug delivery device, where the instructions are configured to control a drug delivery rate by the drug delivery device.
1. A system comprising:
an eye-mountable device including a polymeric material;
an electrochemical sensor mounted in the eye-mountable device, wherein the electrochemical sensor provides one or more sensor measurements indicative of glucose concentration in a tear-film contacting the eye-mountable device;
a reader including one or more antennas, wherein the reader: (i) transmits radio frequency (RF) radiation to power the eye-mountable device and the electrochemical sensor, and (ii) receives indications of the one or more sensor measurements; and
a controller in communication with the reader, wherein the controller: (i) receives information related to the one or more sensor measurements from the reader; (ii) obtains a target value for glucose concentration in the tear-film; (iii) compares the glucose concentration in the tear-film to the target value for glucose concentration in the tear-film; and (iv) based on the comparing, provides instructions to an insulin delivery device to control an insulin delivery rate to a blood stream by the insulin delivery device so as to reduce discrepancy between the glucose concentration in the tear-film and the target value for glucose concentration in the tear-film.
2. The system of claim 1 , wherein the controller is integrated into: (i) the reader, (ii) the insulin delivery device, or (iii) a remote device in communication with the reader and the insulin delivery device.
3. The system of claim 1 , wherein the eye-mountable device further includes a reagent that selectively reacts with an analyte in the tear-film contacting the eye-mountable device, and wherein the reagent is localized proximate the electrochemical sensor.
4. The system of claim 1 , wherein the reader transmits the RF radiation to power the eye-mountable device and the electrochemical sensor at least a predetermined period of time before receiving the indications of the one or more sensor measurements.
5. The system of claim 1 , wherein the polymeric material includes a channel configured to expose the electrochemical sensor to the tear-film contacting the polymeric material of the eye-mountable device.
6. The system of claim 1 , wherein the controller establishes a rate of change of glucose concentration based on the information related to the one or more sensor measurements, wherein the instructions to the insulin delivery device are further based on the established rate of change of glucose concentration.