Modifiable medical grafts and related methods and apparatuses

1. A medical graft for administration to a patient, comprising:

a graft material having a first outer surface and a second outer surface, the graft material defining an internal chamber between the first outer surface and the second outer surface of the graft material;

at least one region of the graft material interrupting the chamber and surrounded by the chamber; and

a thru-hole defined in said at least one region of the graft material, the thru-hole extending between the first outer surface and the second outer surface of the graft material, wherein a peripheral portion of the at least one region of the graft material surrounds the thru-hole and isolates the thru-hole from the internal chamber, and further wherein the thru-hole allows passage of biological fluids of the patient from one side of the graft material to another side of the graft material when the graft material is administered to the patient;

wherein a first wall of the graft material defines a first boundary of the chamber;

wherein a second wall of the graft material defines a second boundary of the chamber;

wherein the first and second walls are laminated to one another to provide said at least one region of the graft material; and

wherein the first wall and the second wall comprise an extracellular matrix material.

2. The medical graft of claim 1 , wherein the thru-hole comprises an elongate slit extending between the first outer surface and the second outer surface of the graft material.

3. The medical graft of claim 1 , wherein the graft material comprises a matrix for supporting cell growth.

4. The medical graft of claim 1 , comprising a plurality of said regions.

5. The medical graft of claim 4 , wherein each of said regions defines a thru-hole.

6. The medical graft of claim 1 , also comprising a peripheral flange defined by the graft material, the peripheral flange extending around said internal chamber.

7. The medical graft of claim 6 , also comprising at least one open passage defined by the graft material of the peripheral flange, the open passage extending through the flange and opening into the internal chamber.

8. A medical graft apparatus, comprising:

a medical graft of claim 1 ; and

a tray enclosure in which the graft material is received.

9. The medical graft apparatus of claim 8 , wherein the tray enclosure compresses the graft material in selected regions.

10. A medical graft apparatus, comprising:

a medical graft of claim 1 ; and

a sterile enclosure sterilely enclosing the medical graft.

11. A method for preparing a medical graft material, comprising:

delivering liquid additive to the graft material of a medical graft of claim 1 .

12. A medical graft device for administration to a patient, comprising:

a graft material defining an internal chamber and a peripheral flange around said internal chamber, the graft material comprising a porous matrix material configured to allow cellular invasion and ingrowth into the porous matrix material, the graft material having a first side and a second side, with the first side and the second side defining outermost surfaces of the medical graft device;

a plurality of regions of the graft material interrupting the chamber and surrounded by the chamber, said regions defining portions of said first side and portions of said second side, and said regions being discrete from one another and separated from one another by portions of the chamber;

wherein a first wall of the graft material defines a first boundary of the chamber and a second wall of the graft material defines a second boundary of the chamber;

wherein the first and second walls are bonded to one another to provide said regions of the graft material; and

wherein a thru-hole is defined in each of said regions of the graft material, the thru-hole extending between the first side outermost surface and the second side outermost surface of the graft material, wherein a peripheral portion of each of said regions of the graft material surrounds the thru-hole and isolates the thru-hole from the internal chamber, and further wherein the thru-hole allows passage of biological fluids of the patient from one side of the graft material to another side of the graft material when the graft material is administered to the patient.

13. The medical graft device of claim 12 , also comprising an open passage defined by the graft material, the open passage extending through the flange and opening into the internal chamber, and a cannula removably received in the passage.

14. The medical graft device of claim 13 , also comprising a fluid injection device fluidly coupled to said cannula.

15. A medical graft apparatus, comprising:

a tray enclosure;

a medical graft device according to claim 12 received in the tray enclosure; and

wherein the tray enclosure compresses the graft material of the medical graft device in selected areas.

16. The medical graft apparatus of claim 15 , wherein said selected areas create a periphery of compressed graft material around an inner region of uncompressed graft material.

17. The medical graft apparatus of claim 16 , wherein said inner region comprises said internal chamber of said graft material.

18. The medical graft apparatus of claim 15 , wherein said selected areas bound an open passage of said graft material.

19. The medical graft device of claim 12 , wherein the porous matrix material comprises an extracellular matrix material.

20. The medical graft device of claim 19 , wherein the extracellular matrix material is a remodelable extracellular matrix material.

21. The medical graft device of claim 20 , wherein the remodelable extracellular matrix material retains native growth factors from a source tissue for the remodelable extracellular matrix material.

22. The medical graft device of claim 12 , wherein the porous matrix material comprises a resorbable synthetic polymeric material.

23. A medical product, comprising:

a medical graft including:

a graft material having a first outer surface and a second outer surface, the graft material defining an internal chamber between the first outer surface and the second outer surface of the graft material;

at least one region of the graft material interrupting the chamber and surrounded by the chamber; and

a thru-hole defined in said at least one region of the graft material, the thru-hole extending between the first outer surface and the second outer surface of the graft material, wherein a peripheral portion of the at least one region of the graft material surrounds the thru-hole and isolates the thru-hole from the internal chamber, and further wherein the thru-hole allows passage of biological fluids of a patient from one side of the graft material to another side of the graft material when the graft material is administered to the patient; and

a liquid additive applied to the graft material, wherein the liquid additive includes cells.

24. A method of treating a patient, comprising:

grafting tissue of the patient with a medical graft material prepared by a method including delivering liquid additive to the graft material of a medical graft, wherein the medical graft comprises:

the graft material having a first outer surface and a second outer surface, the graft material defining an internal chamber between the first outer surface and the second outer surface of the graft material;

at least one region of the graft material interrupting the chamber and surrounded by the chamber; and

a thru-hole defined in said at least one region of the graft material, the thru-hole extending between the first outer surface and the second outer surface of the graft material, wherein a peripheral portion of the at least one region of the graft material surrounds the thru-hole and isolates the thru-hole from the internal chamber, and further wherein the thru-hole allows passage of biological fluids of the patient from one side of the graft material to another side of the graft material when the graft material is administered to the patient.

25. The method of claim 24 , wherein the graft material comprises a porous matrix material configured to allow cellular invasion and ingrowth into the porous matrix material, and wherein the liquid additive includes cells, a growth factor, a pharmaceutical agent, platelets, platelet rich plasma, platelet lysate, a blood fraction, or a bone marrow fraction.

26. The method of claim 25 , wherein the porous matrix material comprises an extracellular matrix material.