IP Library Granted Patent US 8,728,117
Granted Patent B1
US 8,728,117 · App. 14/093,831 · Granted May 20, 2014

Flow disrupting devices

Inventors: Vallabh Janardhan (Dallas, TX); Vikram Janardhan (Sacramento, CA)
Assignee: Insera Therapeutics, Inc.
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Quick Facts
Patent No.
US 8,728,117
App. No.
14/093,831
Granted
May 20, 2014
Kind
B1
Abstract

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measureable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Claims (58)

1. A device for treating a vascular cavity, the device comprising:

a plurality of wires woven to form a textile structure expandable between a radially compressed state and a radially expanded state, the textile structure in the radially expanded state comprising:

a first bulb, the first bulb having a first braid angle, the first bulb having a first diameter, the first bulb having a porosity configured to decrease flow into and out of the vascular cavity,

a second bulb, the second bulb having a second braid angle less than the first braid angle, the second bulb having a second diameter,

a third bulb, the second bulb between the first bulb and the third bulb, the third bulb having a third braid angle less than the first braid angle, the third bulb having a third diameter less than the first diameter,

a first neck between the first bulb and the second bulb, the first neck having a fourth braid angle less than the first braid angle, the first neck having a fourth diameter less than the first diameter and the second diameter,

a second neck between the second bulb and the third bulb, the second neck having a fifth braid angle less than the first braid angle, the second neck having a fifth diameter less than the second diameter and the third diameter,

a third neck extending from the third bulb, and

a fourth neck extending from the first bulb.

2. The device of claim 1 , wherein the textile structure in the radially expanded state further comprises:

a fourth bulb between the first bulb and the first neck, the fourth bulb having a sixth braid angle greater than the second braid angle, the third braid angle, the fourth braid angle, and the fifth braid angle, the fourth bulb having a sixth diameter, and

a fourth neck between the first bulb and the fourth bulb, the fourth neck having a seventh diameter less than the first diameter and the sixth diameter.

3. The device of claim 2 , wherein the sixth diameter is less than the first diameter and greater than the third diameter.

4. The device of claim 2 , wherein the fourth bulb has a porosity configured to decrease flow into the vascular cavity.

5. The device of claim 1 , wherein each of the first bulb, the second bulb, and the third bulb has a shape of an ellipsoid or oblate spheroid having a polar axis diameter smaller than an equatorial axis diameter.

6. The device of claim 5 , wherein the first bulb, the second bulb, and the third bulb are coupled along the polar axes of the first bulb, the second bulb, and the third bulb.

7. The device of claim 1 , wherein the textile structure is mechanically or electrolytically detachable from a proximal portion at a joint.

8. The device of claim 1 , wherein the first braid angle is between 91° and 180°.

9. The device of claim 1 , further comprising a proximal portion detachably coupled to the textile structure, wherein each of the first bulb, the second bulb, and the third bulb has a shape of an ellipsoid or oblate spheroid having a polar axis diameter smaller than an equatorial axis diameter, wherein the first bulb, the second bulb, and the third bulb are coupled along the polar axes of the first bulb, the second bulb, and the third bulb, and wherein the textile structure in the radially expanded state further comprises:

a fourth bulb between the first bulb and the first neck, the fourth bulb having a sixth braid angle greater than the second braid angle, the third braid angle, the fourth braid angle, and the fifth braid angle, the fourth bulb having a sixth diameter less than the first diameter and greater than the third diameter, wherein the fourth bulb has a porosity configured to decrease flow into the vascular cavity, and

a fourth neck between the first bulb and the fourth bulb, the fourth neck having a seventh diameter less than the first diameter and the sixth diameter.

10. A device for treating a vascular cavity, the device comprising:

a textile structure changeable between a radially compressed state and a radially expanded state,

the textile structure comprising, in the radially expanded state, a plurality of bulbs along a longitudinal axis from a proximal end to a distal end, wherein the plurality of bulbs comprises a proximal-most bulb having a first braid angle, at least one bulb distal to the proximal-most bulb having a second braid angle less than the first braid angle,

each said bulb longitudinally spaced from another said bulb by a neck, at least one neck distal to the proximal-most bulb having a third braid angle less than the first braid angle,

the proximal-most bulb of the plurality of bulbs having a porosity configured to reduce flow into the vascular cavity; and

a proximal portion coupled to the textile structure at a joint proximal to the proximal-most bulb,

the textile structure detachable from the proximal portion at the joint.

11. The device of claim 10 , wherein the plurality of bulbs comprises:

a second bulb distal to the proximal-most bulb, the second bulb having the second braid angle; and

a third bulb distal to the second bulb, the third bulb having a fourth braid angle less than the first braid angle.

12. The device of claim 10 , wherein the plurality of bulbs comprises:

a second bulb distal to the proximal-most bulb, the second bulb having a fourth braid angle;

a third bulb distal to the second bulb, the third bulb having the second braid angle less than the first braid angle and the fourth braid angle; and

a fourth bulb distal to the third bulb, the fourth bulb having a fifth braid angle less than the first braid angle and the fourth braid angle.

13. The device of claim 10 , wherein each of the plurality of bulbs has a shape of an ellipsoid or oblate spheroid having a polar axis diameter smaller than an equatorial axis diameter.

14. The device of claim 13 , wherein the plurality of bulbs are coupled along the polar axes.

15. The device of claim 10 , wherein the textile structure is mechanically detachable from the proximal portion at the joint.

16. The device of claim 10 , wherein the textile structure is electrolytically detachable from the proximal portion at the joint.

17. The device of claim 10 , wherein the plurality of bulbs comprises:

a second bulb distal to the proximal-most bulb, the second bulb having the second braid angle;

a third bulb distal to the second bulb, the third bulb having the second braid angle; and

a distal neck distal to a distal-most bulb of the plurality of bulbs, the distal neck having a free distal end,

wherein each of the plurality of bulbs has a shape of an ellipsoid or oblate spheroid having a polar axis diameter smaller than an equatorial axis diameter,

wherein the plurality of bulbs are coupled along the polar axes,

wherein the first braid angle is between 91° and 180°, and

wherein the textile structure is completely hollow.

18. A device for treating a vascular cavity, the device comprising:

a structure transformable between a radially compressed state and a radially expanded state,

the structure comprising, in the radially expanded state, a plurality of bulbs, wherein the plurality of bulbs comprises a proximal-most bulb having a first braid angle, at least one bulb distal to the proximal-most bulb having a second braid angle less than the first braid angle,

each said bulb longitudinally spaced from another said bulb by a neck, at least one neck distal to the proximal-most bulb having a third braid angle less than the first braid angle,

the proximal-most bulb having a porosity configured to inhibit flow into the vascular cavity.

19. The device of claim 18 , wherein the structure comprises a plurality of wires, and wherein the plurality of bulbs comprises:

a second bulb distal to the proximal-most bulb, the second bulb having the second braid angle; and

a third bulb distal to the second bulb, the third bulb having the second braid angle,

wherein the first braid angle is between about 91° and about 180°, and

wherein the textile structure is completely hollow.

20. The device of claim 18 , wherein each of the plurality of bulbs has a shape of an ellipsoid or oblate spheroid having a polar axis diameter smaller than an equatorial axis diameter and wherein the plurality of bulbs are coupled along the polar axes.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Sep 9, 2021
From: KNOBBE, MARTENS, OLSON & BEAR, LLP
To: INSERA THERAPEUTICS, INC.
Reel/Frame 057454/0677 →
SECURITY INTEREST Recorded Jun 30, 2020
From: INSERA THERAPEUTICS, INC.
To: KNOBBE, MARTENS, OLSON & BEAR, LLP
Reel/Frame 053095/0350 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 2, 2013
From: JANARDHAN, VALLABH; JANARDHAN, VIKRAM
To: INSERA THERAPEUTICS, INC.
Reel/Frame 031698/0728 →
Continuity (1)
Continuation 13953540 · Jul 29, 2013