IP Library Granted Patent US 9,522,163
Granted Patent B2
US 9,522,163 · App. 14/094,140 · Granted Dec 20, 2016

Methods of treating hepatitis

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Quick Facts
Patent No.
US 9,522,163
App. No.
14/094,140
Granted
Dec 20, 2016
Kind
B2
Abstract

The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.

Claims (13)

1. A method of treating hepatitis in a patient at risk of acute liver failure, comprising:

identifying a patient diagnosed as suffering from hepatitis that is not a post-operative result of liver transplantation, and who is at risk of acute liver failure; and

administering to the patient by inhalation a gaseous pharmaceutical composition comprising from 100 ppm to 800 ppm of carbon monoxide for up to six hours per day to reduce hepatocyte death in the patient.

2. The method of claim 1 , wherein the patient is infected with a virus selected from the group consisting of: hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus, hepatitis E virus, and hepatitis G virus.

3. The method of claim 1 , wherein the patient is an alcoholic.

4. The method of claim 1 , further comprising administering antiviral agents to the patient.

5. The method of claim 1 , wherein the hepatitis is caused by exposure to a hepatotoxic agent.

6. The method of claim 1 , wherein administering the gaseous composition comprising carbon monoxide comprises:

providing a vessel containing a pressurized gas comprising carbon monoxide gas;

releasing the pressurized gas from the vessel, to form an atmosphere comprising carbon monoxide gas; and

exposing the patient to the atmosphere.

7. The method of claim 1 , further comprising withholding or reducing administration of hepatitis-inducing drugs.

8. The method of claim 1 , further comprising administering corticosteroids to the patient.

Assignments (3)
CONFIRMATORY LICENSE Recorded May 27, 2015
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035782/0535 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2014
From: OTTERBEIN, LEO E.; CHOI, AUGUSTINE M. K.
To: YALE UNIVERSITY
Reel/Frame 032101/0047 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2014
From: ZUCKERBRAUN, BRIAN SCOTT
To: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 032101/0109 →