Controlled release compositions and methods of using
View Patent ↗Cyclodextrin compositions, including a hydrophobic carrier and a cyclodextrin complex, are formed and disposed on a variety of substrates using conditions that avoid substantial loss of the complexed compound from the cyclodextrin complex, even where the complexed compound is a gas a common ambient temperatures (e.g. 20° C.). Flexographic printing is particularly useful for disposing the cyclodextrin compositions on one or more substrates. Substrates treated with the cyclodextrin complexes are useful for subsequent release of the complexed compound.
1. A method of making a treated substrate, the method comprising
heating the composition to a temperature between 60° C. and 80° C., the composition consisting essentially of
a cyclodextrin inclusion complex comprising a cyclodextrin compound and an olefinic inhibitor; and
a carrier comprising petrolatum or a petrolatum-like material, wherein the carrier has a melting transition onset between about 23°C and 40°C, and solubility in water of less than 1 wt % at 25°C; and
disposing the heated composition on a first substrate using a flexographic printing press.
2. The method of claim 1 further comprising cooling the treated substrate, wherein the cooling is accomplished using a chill roll on the flexographic printing press.
3. The method of claim 1 wherein the disposing comprises a discontinuous printed pattern such that the treated substrate comprises 50% or less of the available substrate surface area having the composition disposed thereon.
4. The method of claim 1 further comprising contacting the composition with a second substrate after the disposing.
5. The method of claim 4 wherein an adhesive is disposed between the first substrate and the second substrate.