Topical preparation for pain relief
A composition for pain relief including synergistically effective amounts of an amino benzoate local anesthetic, methylsulfonylmethane (MSM), and ethoxydiglycol. A method of treating pain, by applying the composition to skin in an area of pain, and blocking nerve signals. A method of improving range of motion in an individual, by applying the composition to skin, relieving pain, and allowing the individual to have an improved range of motion at an area of pain.
1. A method of reducing a sensation of pain in a subject, comprising:
applying topically directly to skin of the subject over an area of pain a therapeutic amount of a composition comprising
(a) lidocaine in an amount of about 1% to about 20%; and
(b) a penetration enhancer comprising a penetration-enhancing amount of a methylsulfonylmethane (MSM) component, and an ethoxydiglycol component, wherein the amount of the MSM component is about 1% to about 10%, and the amount of the ethoxydiglycol component is about 0.10% to about 5%,
wherein the composition is effective
(i) to deeply penetrate the skin of the subject,
(ii) to remain in the skin and block nerve signals affecting sensation of pain, and
(iii) to provide pain relief.
2. The method of claim 1 , wherein the pain is caused by a condition selected from the group consisting of a tear, tendonosis, supraspinatus acute tendonitis, chronic tendonitis, rotator cuff disease, neck and low back pain, herpes zoster, insect bites and stings, neuropathy, and migraine headaches.
3. The method of claim 1 , wherein the pain is caused by insect bites and stings, the composition further includes a therapeutic selected from the group consisting of cortisone and hydrocortisone, and the therapeutic amount is effective to provide an anti-inflammatory effect.
4. The method of claim 1 , wherein the pain is caused by migraine headaches, the composition further includes a therapeutic selected from the group consisting of a vasoconstrictor, an anti-inflammatory agent, and combinations thereof, and the therapeutic amount is effective to provide an anti-inflammatory effect.
5. The method of claim 1 , wherein the pain is caused by migraine headaches and the therapeutic effect further includes relaxing muscles that otherwise constrict around vessels blocking circulation and around nerves being impinged.
6. The method of claim 1 , wherein the administering is at multiple sites of the body.
7. The method of claim 1 , further including administering an anti-pain and anti-inflammatory agent selected from the group consisting of acetaminophen, aspirin, diflunisal, salsalate, indomethacin, ketorolac, sulindac, etodolac, diclofenac, nabumetone, ibuprofen, naproxen, flurbiprofen, ketoprofen, oxaprozin, fenoprofen, loxoprofen, meclofenamic acid, mefenamic acid, flufenamic acid, tolfenamic acid, piroxicam, meloxicam, tenoxicam, droxicam, lornoxicam, isoxicam, tolmetin, celecoxib, rofecoxib, valdecoxib, parecoxib, lumiracoxib, etoricoxib, firocoxib, steroids, and lidocaine.
8. A method of improving range of motion in an individual, including applying topically directly to the skin of the individual over an area of pain a therapeutic amount of a composition comprising
(a) lidocaine in an amount of about 1% to about 20%, and
(b) a penetration enhancer comprising a penetration-enhancing amount of a methylsulfonylmethane (MSM) component and a ethoxydiglycol component, wherein the amount of the MSM component is about 1% to about 10%, and the amount of the ethoxydiglycol component is about 0.10% to about 5%;
wherein the composition is effective
(i) to deeply penetrate the skin of the subject,
(ii) to remain in the skin of the subject and block nerve signals affecting sensation of pain; and
(iii) to improve range of motion at the area of pain by providing pain relief in the area of pain.
9. The method of claim 8 , further including administering an anti-pain and anti-inflammatory agent selected from the group consisting of acetaminophen, aspirin, diflunisal, salsalate, indomethacin, ketorolac, sulindac, etodolac, diclofenac, nabumetone, ibuprofen, naproxen, flurbiprofen, ketoprofen, oxaprozin, fenoprofen, loxoprofen, meclofenamic acid, mefenamic acid, flufenamicacid, tolfenamic acid, piroxicam, meloxicam, tenoxicam, droxicam, lornoxicam, isoxicam, tolmetin, celecoxib, rofecoxib, valdecoxib, parecoxib, lumiracoxib, etoricoxib, firocoxib, steroids, and lidocaine.
10. The method of claim 1 , wherein the lidocaine is present in an amount of about 4% to about 10%.