IP Library › Patent Application 14098995
Patent Application
App. No. 14/098,995

Factor IX: Remodeling and Glycoconjugation of Factor IX

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Quick Facts
Patent No.
US None
App. No.
14/098,995
Abstract

The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.

Claims (15)

1 - 38 . (canceled)

39 . A covalent conjugate between a Factor IX peptide and a poly(ethylene glycol) that alters a property of said peptide, wherein said poly(ethylene glycol) is covalently attached to said Factor IX peptide at a preselected glycosyl or amino acid residue of said Factor IX peptide via an intact glycosyl linking group.

40 . (canceled)

41 . The covalent conjugate of claim 39 , wherein said poly(ethylene glycol) and an intact glycosyl linking group precursor are linked as a covalently attached unit to said Factor IX peptide via the action of an enzyme, said enzyme converting said precursor to said intact glycosyl linking group, thereby forming said conjugate.

42 . The covalent conjugate of claim 39 comprising:

a first poly(ethylene glycol) covalently linked to a first glycosyl residue of said Factor IX peptide via a first intact glycosyl linking group, and

a second poly(ethylene glycol) covalently linked to a second glycosyl residue of said Factor IX peptide via a second intact glycosyl linking group.

43 . The covalent conjugate of claim 42 , wherein said first glycosyl residue and said second glycosyl residue are structurally identical.

44 . The covalent conjugate of claim 42 , wherein said first glycosyl residue and said second glycosyl residue have different structures.

45 - 46 . (canceled)

47 . The covalent conjugate of claim 39 , wherein said Factor IX peptide is remodeled prior to forming said conjugate.

48 . The covalent conjugate of claim 47 , wherein the remodeled Factor IX peptide is remodeled to introduce an acceptor moiety for said intact glycosyl linking group.

49 - 51 . (canceled)

52 . The covalent conjugate of claim 39 , wherein said poly(ethylene glycol) has a molecular weight distribution that is essentially homodisperse.

53 - 112 . (canceled)