IP Library › Granted Patent US 9,114,089
Granted Patent B2
US 9,114,089 · App. 14/100,514 · Granted Aug 25, 2015

Modulation of thymosin beta-4 in skin

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Quick Facts
Patent No.
US 9,114,089
App. No.
14/100,514
Granted
Aug 25, 2015
Kind
B2
Abstract

Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.

Claims (7)

1. A method for cosmetically improving the aesthetic appearance of human skin comprising topically applying to an area of the human skin in need thereof a composition comprising a cosmetically a effective amount of a synthetic compound selected from the group consisting of:

and combinations thereof for a time sufficient to cosmetically improve the aesthetic appearance of said human skin.

2. The method of claim 1 , wherein the composition further comprises a cosmetically acceptable vehicle.

3. The method of claim 1 , wherein the synthetic compound is Compound 1.

4. The method of claim 1 , wherein the synthetic compound is Compound 2.

5. The method of claim 1 , wherein the synthetic compound is Compound 3.

6. The method of claim 1 , wherein synthetic compound is Compound 4.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Jan 28, 2026
From: NATURA &CO LUXEMBOURG HOLDINGS S.À R.L., AS A SECURED PARTY; NATURA &CO UK HOLDINGS LIMITED, AS A SECURED PARTY
To: AVON PRODUCTS, INC.
Reel/Frame 074508/0281 →
RELEASE OF SECURITY INTEREST Recorded Dec 11, 2024
From: NATURA &CO HOLDING S.A.; NATURA COSMETICOS S.A.; NATURA &CO LUXEMBOURG HOLDINGS S.A R.L. - LUXEMBOURG; NATURA &CO UK HOLDINGS LIMITED - UK
To: AVON PRODUCTS, INC
Reel/Frame 069591/0494 →
PATENT SECURITY AGREEMENT Recorded Aug 16, 2024
From: AVON PRODUCTS, INC.
To: NATURA &CO HOLDING S.A.; NATURA &CO LUXEMBOURG HOLDINGS S.À R.L.; NATURA COSMÉTICOS S.A.; NATURA &CO UK HOLDINGS LIMITED
Reel/Frame 068659/0915 →
SECURITY INTEREST Recorded Apr 29, 2024
From: AVON PRODUCTS, INC.; MI HOLDINGS, INC.; AVON INTERNATIONAL OPERATIONS, INC.; AVON CAPITAL CORPORATION; AVON COSMETICS LIMITED; AVON BEAUTY LIMITED
To: NATURA &CO HOLDING S.A., AS SECURED PARTY; NATURA &CO LUXEMBOURG HOLDINGS S.À R.L., AS A SECURED PARTY; NATURA COSMÉTICOS S.A., AS A SECURED PARTY
Reel/Frame 067249/0491 →
SECURITY INTEREST Recorded Aug 11, 2023
From: AVON PRODUCTS, INC.
To: NATURA &CO LUXEMBOURG HOLDINGS S.À R.L., AS A SECURED PARTY; NATURA &CO UK HOLDINGS LIMITED, AS A SECURED PARTY
Reel/Frame 064566/0872 →
SECURITY INTEREST Recorded Nov 14, 2019
From: AVON PRODUCTS, INC.
To: CITIBANK, N.A., LONDON BRANCH
Reel/Frame 051032/0210 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Aug 15, 2016
From: CITIBANK, N.A.
To: AVON PRODUCTS, INC.
Reel/Frame 039690/0331 →
SECURITY INTEREST Recorded Jun 12, 2015
From: AVON PRODUCTS, INC.
To: CITIBANK, N.A.
Reel/Frame 035899/0776 →