IP Library › Granted Patent US 9,220,792
Granted Patent B2
US 9,220,792 · App. 14/103,188 · Granted Dec 29, 2015

Modified polynucleotides encoding aquaporin-5

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Quick Facts
Patent No.
US 9,220,792
App. No.
14/103,188
Granted
Dec 29, 2015
Kind
B2
Abstract

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and modified mRNA (mmRNA) molecules.

Claims (7)

1. A method of producing Aquaporin-5 in a mammalian cell, tissue or organism comprising contacting said mammalian cell, tissue or organism with an mRNA encoding SEQ ID NO: 821, wherein said mRNA comprises a coding region having at least 80% identity to SEQ ID NO: 6594.

2. The method of claim 1 , wherein the mRNA comprises at least one untranslated region 5′ relative to the coding region and at least one untranslated region 3′ relative to the coding region.

3. The method of claim 2 , wherein the 5′ untranslated region is heterologous to the coding region of the mRNA.

4. The method of claim 2 , wherein the 3′ untranslated region is heterologous to the coding region of the mRNA.

5. The method of claim 2 , wherein the 5′ untranslated region and the 3′ untranslated region are heterologous to the coding region of the mRNA.

6. The method of claim 2 , wherein the mRNA comprises at least two stop codons.

7. The method of claim 1 , wherein the coding region is selected from the group consisting of SEQ ID NO: 6594, 6574, 6584, 6606, 6612, 6613 and 6617.

Assignments (4)
SECURITY INTEREST Recorded Nov 19, 2025
From: MODERNATX, INC.
To: ARES CAPITAL CORPORATION, AS AGENT
Reel/Frame 073634/0354 →
CHANGE OF NAME Recorded Mar 28, 2018
From: MODERNA THERAPEUTICS, INC.
To: MODERNATX, INC.
Reel/Frame 045755/0844 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INVENTOR NAME TO READ RON WEISS PREVIOUSLY RECORDED ON REEL 032052 FRAME 0791. ASSIGNOR(S) HEREBY CONFIRMS THE INVENTOR NAME CURRENTLY READS RONALD WEISS. Recorded Jan 29, 2014
From: BANCEL, STEPHANE; CHAKRABORTY, TIRTHA; DE FOUGEROLLES, ANTONIN; WHORISKEY, SUSAN; WEISS, RON
To: MODERNA THERAPEUTICS, INC.
Reel/Frame 032141/0394 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 27, 2014
From: BANCEL, STEPHANE; CHAKRABORTY, TIRTHA; DE FOUGEROLLES, ANTONIN; WHORISKEY, SUSAN; WEISS, RONALD
To: MODERNA THERAPEUTICS, INC.
Reel/Frame 032052/0791 →