Compounds as antagonists or inverse agonists of opioid receptors for treatment of addiction
Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.
1. A method of treatment comprising administering a compound which is N-{[3,5-difluoro-3′-(1H-1,2,4-triazol-3-yl)-4-biphenylyl]methyl}-2,3-dihydro-1H-inden-2-amine or a salt thereof to a human suffering from drug addiction, substance addiction, or a combination thereof.
2. The method of claim 1 wherein said compound is a citrate, phosphate or mono- or di-hydrochloride salt of N-{[3,5-difluoro-3′-(1H-1,2,4-triazol-3-yl)-4-biphenylyl]methyl}-2,3-dihydro-1H-inden-2-amine.
3. The method of claim 2 wherein said compound is the citrate salt.
4. The method of claim 2 wherein said compound is the phosphate salt.
5. The method of claim 2 wherein said compound is the mono- or di-hydrochloride salt.
6. A method of treatment comprising administering a pharmaceutical composition comprising (i) a compound which is N-{[3,5-difluoro-3′-(1H-1,2,4-triazol-3-yl)-4-biphenylyl]methyl}-2,3-dihydro-1H-inden-2-amine or a salt thereof and (ii) at least one carrier or excipient to a human suffering from drug addiction, substance addiction, or a combination thereof.
7. The method of claim 6 wherein said compound is a citrate, phosphate or mono- or di-hydrochloride salt of N-{[3,5-difluoro-3′-(1H-1,2,4-triazol-3-yl)-4-biphenylyl]methyl}-2,3-dihydro-1H-inden-2-amine.
8. The method of claim 6 wherein said compound is the citrate salt.
9. The method of claim 6 wherein said compound is the phosphate salt.
10. The method of claim 6 wherein said compound is the mono- or di-hydrochloride salt.