Topical DNA repair composition
View Patent ↗Provided herein are topical compositions for repairing sun damaged skin and topical sunscreen compositions for both preventing and repairing sun damage.
1. A topical sunscreen composition for repairing and reducing the incidence of sun damaged skin comprising:
one or more DNA repair enzymes selected from the group consisting of: photolyase from Anacystis nidulans, UV endonuclease from Micrococcus luteus, and OGG1 from Arabidopsis thaliana;
liposomes containing said one or more DNA repair enzymes; a peptone or synthesized peptide comprising a metal atom binding site; a metal atom bound to said metal binding site;
wherein the liposomes comprise phospholipids, oleic acid, and cholesterol
wherein the liposomes are about 200 nm in diameter; and
a topically suitable carrier
wherein the one or more enzymes are present in a cell extract.
2. The topical composition of claim 1 , wherein the metal binding site comprises a nitrogen atom from at least two amino acids selected from Gly, Ala, Arg, His, and Lys.
3. The topical composition of claim 1 , wherein the peptide consists of 3 amino acids
wherein the 3 amino acids have the sequence Gly-His-Lys.
4. The topical composition of claim 1 , wherein the peptide consists of 3 amino acids,
wherein the 3 amino acids have the sequence Ala-His-Lys.
5. The topical composition of claim 1 , wherein the metal atom is copper (II), cadmium (II), tin (II), cobalt (II), iron (II), or manganese (II).