Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)

1. A compound of Formula II:

wherein

W is —C(O)—, —S(O)—, or —S(O) 2 —;

R is an aryl or bicyclic heteroaryl;

wherein said heteroaryl contains 1, 2, or 3 heteroatoms independently selected from N, S, and O, with the proviso that no two adjacent ring heteroatoms are both S or both O; and

each of said aryl or heteroaryl is optionally substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy, —CONH 2 , —C(O)NH(alkyl), —C(O)N(alkyl) 2 , —C(O)NH(aryl), —C(O)N(aryl) 2 , —CF 3 , —CHF 2 , —CH 2 F, -alkyl, alkoxy, hydroxyl, hydroxyalkyl, (alkoxyalkyl)amino, —N(R 3 )—C(O)-alkyl, —N(R 3 )—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, with the proviso that no two adjacent ring heteroatoms in said heteroaryl are both S or both O;

G is aryl, heteroaryl, cycloalkyl, heterocycloalkyl or —NR 1 R 2 ;

wherein each of said aryl, heteroaryl, heterocycloalkyl, and cycloalkyl is either unsubstituted or substituted with 1, 2, 3, or 4 substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy-, —CONH 2 , —C(O)NH(alkyl), —C(O)N(alkyl) 2 , —C(O)NH(aryl), —C(O)N(aryl) 2 , —CF 3 , —CHF 2 , —CH 2 F, alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, hydroxyalkyl, aryloxy, (alkoxyalkyl)amino, —N(R 3 )—C(O)-alkyl, —N(R 3 )—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and

R 1 and R 2 are the same or they are different, and are independently selected from H, C 1 to C 7 alkyl, C 1 to C 7 alkoxy, C 1 to C 4 hydroxyalkyl, aryl, heteroaryl, heterocycloalkyl, and cycloalkyl, and

wherein heteroatoms of said heteroaryl and heterocycloalkyl are independently selected from N, O, and S, with the proviso that no two adjacent ring heteroatoms are both S or both O; and

further wherein R 1 and R 2 are each unsubstituted or optionally substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy, —CONH 2 , —C(O)NH(alkyl), —C(O)N(alkyl) 2 , —C(O)NH(aryl), —C(O)N(aryl) 2 , —CF 3 , —CHF 2 , —CH 2 F, alkyl, hydroxyalkyl, -alkoxy, hydroxyl, hydroxyalkyl, carboxy, (alkoxyalkyl)amino, -alkylamine, aminocarbonyl, —CHO, —N(R 3 )—C(O)-alkyl, —N(R 3 )—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;

R 3 is H, alkyl or arylalkyl; and

n is 4, 5 or 6;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein W is —C(O)—.

3. The compound of claim 1 , wherein W is —S(O) 2 —.

4. The compound of claim 1 , wherein n is 4.

5. The compound of claim 1 , wherein R 3 is H.

6. The compound of claim 1 , wherein R is selected from the group consisting of thienopyridine, 1H-pyrrolopyidine, pyrrolopyidine, imidazopyridine, pyrazolopyridine, quinolone, and furopyridine, each optionally substituted.

7. The compound of claim 1 , wherein R is selected from the group consisting of thieno[2,3-c]pyridin-2-yl, 1H-pyrrolo[3,2-c]pyidin-2-yl, 1H-pyrrolo[3,2-c]pyidin-2-yl, imidazo[1,2-a]pyridin-6-yl, pyrazolo[3,4-b]pyridin-5-yl, quinolin-6-yl, and furo[2,3-c]pyridin-2-yl.

8. The compound of claim 1 , wherein G is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each optionally substituted.

9. The compound of claim 1 , wherein G is selected from the group consisting of phenyl, thiazole, pyridine, piperidine, imidazole, furan, oxazole, pyridine, cyclohexyl, indole, benzodioxolane, benzothiophene, benzothiazole, imidazopyridine, and aza-indole, each optionally substituted.

10. The compound of claim 1 , wherein G is selected from the group consisting of phenyl, thiazol-4-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, indol-2-yl, indol-6-yl, imidazol-2-yl, imidazol-4-yl, piperidin-4-yl, furan-3-yl, oxazol-4-yl, pyridin-2-yl, cyclohexyl, benzodioxolane, benzothiophene, benzothiazole, imidazol[1,2-a]pyridin-6-yl, and 1H-pyrrolo[3,2-c]pyidin-2-yl, each optionally substituted.

11. The compound of claim 1 , wherein G is substituted with 1-4 substituents selected from the group consisting of halo, amino, cyano, hydroxyl, alkyl, haloalkyl, alkoxy, acyl, haloalkoxy, aryl, heteroaryl, alkoxyalkyl, and mercapto.

12. The compound of claim 1 , wherein G is substituted with 1-3 substituents selected from the group consisting of halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, aryl, and heteroaryl.

13. The compound of claim 1 , wherein G is selected from the group consisting of imidazo[1,2-a]pyridine-6-yl, 1H-pyrrolo[3,2-c]pyridine, thieno[2,3-c]pyridin-2-yl, and furo[2,3-c]pyridin-2-yl, each optionally substituted.

14. The compound of claim 1 , wherein G is thieno[2,3-c]pyridin-2-yl or imidazo[1,2-a]pyridine.

15. A compound selected from the group consisting of:

N-(4-{1-[(3,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-4-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethoxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethyl)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[6-(morpholin-4-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(dimethyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-cyclohexanecarbonylpiperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(propan-2-yloxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-fluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-{4-[1-(propane-2-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[2-(2-methyl-1,3-thiazol-4-yl)acetyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(1-methyl-1H-imidazol-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-fluoropyridin-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(dimethyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-fluoro-3-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(4-chlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-fluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(pyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(propan-2-yloxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,6-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(pyridin-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(3-(1-benzoylpiperidin-4-yl)propyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(difluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,6-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,3-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(4-chlorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-fluoro-5-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[5-(methoxymethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[4-(propan-2-yl oxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-chlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,6-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-6-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,3-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-benzoylazetidin-3-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(furan-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,3-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-methylpyrazin-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,3-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-cyclohexanecarbonylpiperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(5-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-ethoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-{4-[1-(benzenesulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2, 3-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-difluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(difluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-fluoro-3-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-methylpyrazin-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2H-1,3-benzodioxol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-fluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(5-chloro-2-methoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(3-chloro-4-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-methoxy-3-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-cyclohexanecarbonylpiperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,6-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-{[4-({4-[(pyrrolidin-1-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

N-[4-(1-{[5-(methoxymethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,5-difluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[6-(propan-2-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(3-fluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(3,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2, 3-c]pyridine-2-carboxamide

N-(4-{1-[(2-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethyl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(5-fluoropyridin-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(5-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[6-(morpholin-4-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(dimethyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[2-(2-methyl-1,3-thiazol-4-yl)acetyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-dimethoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,6-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(5-fluoro-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[2-(1-methyl-1H-indol-3-yl)acetyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(4-fluoro-2-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(3,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-fluoro-2-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-4-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,3-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,5-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-cyanobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-chlorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-{4-[1-(pyridine-3-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethyl)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-chlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[4-(trifluoromethyl)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-chlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethoxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(5-fluoro-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-fluoropyridin-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(4-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(methylsulfanyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(difluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(furan-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-methoxy-5-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2H-1,3-benzodioxol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,3-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-{4-[1-({1H-pyrrolo[3,2-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(4-methyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[2-(trifluoromethyl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2, 3-c]pyridine-2-carboxamide

N-[2-(1-benzoylpiperidin-4-yl)ethyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-{4-[1-({1H-pyrrolo[3,2-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-4-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(3-fluoro-4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[5-(trifluoromethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-dimethoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-methyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-fluoro-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethyl)pyrimidin-5-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(4-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(5-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(6-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1-benzothiophen-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[2-(methylsulfanyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(pyridin-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[5-(trifluoromethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(1,3-benzothiazol-6-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1-methyl-1H-imidazol-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(4-methyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-{[4-({4-[(pyrrolidin-1-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(1,3-benzothiazol-6-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[2-(4-phenylphenyl)ethyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-{4-[1-(5-methyl-1,2-oxazole-4-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[5-(trifluoromethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(pyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[6-(propan-2-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-6-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-benzoylpiperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2, 3-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2, 3-c]pyridine-2-carboxamide

N-(4-{1-[(2-chlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2-fluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[4-(propan-2-yl)-1,3-oxazol-5-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2-methyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-fluoro-3-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[6-(propan-2-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(1-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[5-(propan-2-yl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-benzoylpiperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-chlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(pyridin-3-yl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-ethoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,4-dimethoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,5-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[2-(1-methyl-1H-indol-3-yl)acetyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-{4-[1-({1H-pyrrolo[3,2-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}imidazo[1,2-a]pyridine-6-carboxamide

N-[6-(4-chlorophenoxy)hexyl]quinoline-6-carboxamide

N-(4-{1-[(2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(4-benzoylpiperazin-1-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-chloro-2-methoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{4-[(3-methoxyphenyl)carbonyl]piperazin-1-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2, 3-c]pyridine-2-carboxamide

N-(4-{1-[(5-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,6-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-{4-[1-({imidazo[1,2-a]pyridin-6-yl}carbonyl)piperidin-4-yl]butyl}imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[5-(methoxymethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[3-(trifluoromethyl)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-chlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(3,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(pyridin-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(pyridin-3-yl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(1-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[4-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethyl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(3-fluoro-4-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2H-1,3-benzodioxol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(2,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-{[4-({4-[(pyrrolidin-1-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(pyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(4-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-(benzyloxy)phenethyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(6-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[5-(propan-2-yl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[2-(trifluoromethyl)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[2-(2-methyl-1,3-thiazol-4-yl)acetyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1-benzothiophen-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(1H-pyrazol-1-yl)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3-chlorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-methyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[5-(propan-2-yl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-{4-[1-({thieno[2,3-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3,5-difluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-chloro-4-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(2,3-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-fluoro-3-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(4-chlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[4-(1H-pyrazol-1-yl)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-{4-[1-(1-methyl-1H-pyrazole-3-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(6-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-ethoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-benzoylpiperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(1H-indol-6-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2,3-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-methyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-{2-[1-(benzenesulfonyl)piperidin-4-yl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(propan-2-yl)-1,3-oxazol-5-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-{4-[1-({imidazo[1,2-a]pyridin-6-yl}carbonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-4-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3-fluoro-2-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(3,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[4-(propan-2-yloxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[4-(1H-pyrazol-1-yl)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[2-(trifluoromethyl)pyrimidin-5-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[2-(methylsulfanyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(2-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[2-(pyridin-3-yl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-methylpyrazin-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{1-[(1,3-benzothiazol-6-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-(4-{4-[(3-chlorophenyl)carbonyl]piperazin-1-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(1-benzothiophen-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[3-(trifluoromethoxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[2-(1-methyl-1H-indol-3-yl)acetyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(furan-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[4-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-cyanobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1-methyl-1H-imidazol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[6-(morpholin-4-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide

N-[4-(1-{[4-(trifluoromethyl)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(1H-indol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-fluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[(4-chlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide

N-(4-{1-[6-(trifluoromethyl)pyridine-3-sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(3-(1-benzoylpiperidin-4-yl)butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(4-fluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-[4-(1-{[4-(propan-2-yl)-1,3-oxazol-5-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

N-(4-{1-[(5-chloro-2-methoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide and

N-(4-{1-[(5-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide

and pharmaceutically acceptable salts thereof.

16. A pharmaceutical composition comprising at least one compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.

17. A method of preventing or inhibiting a condition in a patient by administering a therapeutically effective amount of at least one compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein said condition is selected from the group consisting of cancer, ovarian cancer, breast cancer, uterine cancer, colon cancer, cervical cancer, lung cancer, prostate cancer, skin cancer, bladder cancer, pancreatic cancer, leukemia, lymphoma, Hodgkin's disease, non-small cell lung cancer, small cell lung cancer, multiple myeloma, squamous cell cancers, kidney cancer, urethral and bladder cancers, cancers of head and neck, and cancers of the brain and central nervous system.

18. The method of claim 17 , wherein said condition is a cancer.

19. The method of claim 18 , wherein said cancer is selected from the group consisting of leukemia, lymphoma, ovarian cancer, breast cancer, uterine cancer, colon cancer, cervical cancer, lung cancer, prostate cancer, skin cancer, CNS cancer, bladder cancer, pancreatic cancer, and Hodgkin's disease.