Quinazoline derivatives for the treatment of viral infections and further diseases
View Patent ↗This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.
1. A compound of formula (I)
or a pharmaceutically acceptable salt wherein
R 1 is one of the following:
R 2 is hydrogen, halogen, hydroxyl, amine, C 1-7 alkyl, C 1-7 alkylamino, C 1-6 alkoxy, or (C 1-4 )alkoxy-(C 1-4 )alkyl,
R 3 is hydrogen, halogen, hydroxyl, amine, C 1-7 alkyl, C 1-7 alkenyl, C 1-7 alkynyl, C 1-7 alkylamino, C 1-6 alkoxy, or (C 1-4 )alkoxy-(C 1-4 )alkyl,
R 4 is hydrogen, halogen, hydroxyl, amine, C 1-7 alkyl, C 1-7 alkylamino, C 1-6 alkoxy, or (C 1-4 )alkoxy-(C 1-4 )alkyl, and
R 5 is hydrogen, fluorine, chlorine or methyl with the proviso that
R 2 , R 3 , R 4 , and R 5 cannot all be H.
2. A compound of formula (I) according to claim 1 wherein R 5 is hydrogen or fluorine.
3. A compound of claim 1 selected from the group consisting of
and a pharmaceutically acceptable salt thereof.
4. A compound of claim 1 having the structure:
or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients, diluents or carriers.