4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
1. The compound (rac)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine or a salt, solvate, or salt of a solvate thereof.
2. The compound (−)-4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine or a salt, solvate, or salt of a solvate thereof.
3. The compound (+)-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl) methyl] phenyl}-1,3,5-triazin-2-amine or a salt, solvate, or salt of a solvate thereof.
4. A pharmaceutical composition comprising a compound according to claim 1 in combination with an inert, nontoxic, pharmaceutically suitable adjuvant.
5. A pharmaceutical composition comprising a compound according to claim 2 in combination with an inert, nontoxic, pharmaceutically suitable adjuvant.
6. A pharmaceutical composition comprising a compound according to claim 3 in combination with an inert, nontoxic, pharmaceutically suitable adjuvant.
7. A pharmaceutical combination comprising a compound according to claim 1 in combination with at least one or more further active ingredients.
8. A pharmaceutical combination comprising a compound according to claim 2 in combination with at least one or more further active ingredients.
9. A pharmaceutical combination comprising a compound according to claim 3 in combination with at least one or more further active ingredients.
10. A method for the treatment of non-small cell lung carcinoma, prostate carcinoma, cervical carcinoma, colorectal carcinoma, or melanoma comprising administering to a patient in need thereof a compound according to claim 1 .
11. A method for the treatment of non-small cell lung carcinoma, prostate carcinoma, cervical carcinoma, colorectal carcinoma, or melanoma comprising administering to a patient in need thereof a compound according to claim 2 .
12. A method for the treatment of non-small cell lung carcinoma, prostate carcinoma, cervical carcinoma, colorectal carcinoma, or melanoma comprising administering to a patient in need thereof a compound according to claim 3 .