Probiotic compositions and methods
View Patent ↗The present invention features compositions and methods for modulation of the mucosal immune system. The compositions include foods fermented by the probiotic organism, Lactobacillus paracasei CBA L74 (International Depository Accession Number LMG P-24778). Alternatively the compositions can include L. paracasei CBA L74 and a physiologically acceptable carrier. In some embodiments, the L. paracasei CBA L74 can be non-replicating. The compositions can be administered to a subject having or at risk for gastrointestinal disorders related to immaturity of the immune system, infection or disease.
1. A composition comprising a fermented food product, wherein the food product has been fermented by the probiotic bacterium, Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778, and any Lactobacillus paracasei CBA L74 cells present in the composition are dead or have been rendered incapable of cell division.
2. The composition of claim 1 , wherein the food product is a dairy product or a cereal product.
3. The composition of claim 2 , wherein the dairy product is milk, yoghurt, curd, cheese or an infant formula.
4. The composition of claim 2 , wherein the cereal product is rice, wheat, oats, barley, corn, rye, sorghum, millet, or triticale.
5. The composition of claim 1 , wherein the food product is dried.
6. The composition of claim 1 , wherein the food product comprises from about 1×10 2 cfu/g to about 10 12 cfu/g of probiotic bacteria per gram of dry weight.
7. A composition comprising the probiotic bacterium, Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778 and a physiologically acceptable carrier, wherein the Lactobacillus paracasei CBA L74 cells present in the composition are dead or have been rendered incapable of cell division.
8. The composition of claim 7 , wherein the physiologically acceptable carrier is a food product.
9. The composition of claim 8 , wherein the food product is a dairy product or a cereal product.
10. The composition of claim 7 , wherein the food product comprises from about 1×10 2 cfu/g to about 10 12 cfu/g of probiotic bacteria per gram of dry weight.
11. The composition of claim 7 , wherein the physiologically acceptable carrier is a pharmaceutically acceptable carrier.
12. The composition of claim 11 , wherein the probiotic bacterium is in a unit dosage form of about 1×10 2 cfu/g to about 1×10 12 cfu/g dry weight.
13. A composition comprising culture supernatant from probiotic bacterium, Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778, and a physiologically acceptable carrier, wherein any Lactobacillus paracasei CBA L74 cells present in the composition are dead or have been rendered incapable of cell division.
14. The composition of claim 13 , wherein the physiologically acceptable carrier is a food product.