Systems and methods for reducing or preventing backflow in a delivery system
Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.
1. A method of delivering a therapeutic agent to a patient, comprising:
advancing a fluid conduit having a first outer sheath disposed therearound into tissue to compress tissue into a first tissue-receiving space defined between an exterior surface of the fluid conduit and an interior surface of a distal end of the first outer sheath and to urge a nose portion disposed at a location proximal to the first tissue-receiving space into contact with the tissue the nose portion tapering from a reduced distal diameter corresponding to an outside diameter of the first outer sheath to an enlarged proximal diameter corresponding to an outside diameter of a catheter; and
delivering fluid containing the therapeutic agent under positive pressure through the catheter, through the fluid conduit, and into a portion of the tissue adjacent to a distal end of the fluid conduit.
2. The method of claim 1 , further comprising delivering a sealing gel through the fluid conduit, before delivering the fluid containing the therapeutic agent, to fill one or more voids that exist between the fluid conduit and the tissue.
3. The method of claim 1 , wherein tissue compressed into the first tissue-receiving space forms a seal that reduces proximal backflow of fluid ejected from the distal end of the fluid conduit beyond the tissue-receiving space.
4. The method of claim 1 , wherein the interior surface of the distal end of the first outer sheath is at least one of conical, convex, and concave.
5. The method of claim 1 , further comprising controlling delivery of fluid through the fluid conduit based on an output of a microsensor embedded in the fluid conduit.
6. The method of claim 1 , wherein the method is used to treat at least one condition selected from central-nervous-system (CNS) neoplasm, intractable epilepsy, Parkinson's disease, Huntington's disease, stroke, lysosomal storage disease, chronic brain injury, Alzheimer's disease, amyotrophic lateral sclerosis, balance disorders, hearing disorders, and cavernous malformations.
7. The method of claim 1 , wherein the first tissue-receiving space is defined between a substantially rectangular exterior cross-section of the first fluid conduit and a substantially cylindrical interior cross-section of the first outer sheath.
8. The method of claim 1 , wherein the fluid conduit includes a substrate having one or more fluid channels formed on an outer surface of the substrate.
9. The method of claim 8 , wherein the substrate has a rectangular exterior cross-section.
10. The method of claim 8 , wherein the substrate is formed from silicon.