IP Library › Granted Patent US 8,779,109
Granted Patent B2
US 8,779,109 · App. 14/132,919 · Granted Jul 15, 2014

Growth hormones with prolonged in-vivo efficacy

Inventors: Carsten Behrens (Koebenhavn N, DK); Nils Langeland Johansen (Koebenhavn Oe, DK); Henrik Sune Andersen (Holte, DK); Leif Noerskov-Lauritsen (Tappernoeje, DK)
Assignee: Novo Nordisk Health Care AG
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Quick Facts
Patent No.
US 8,779,109
App. No.
14/132,919
Granted
Jul 15, 2014
Kind
B2
Abstract

The invention relates to growth hormone compounds with a protracted profile. The effect is obtained by linking an albumin binding residue via a hydrophilic spacer to growth hormone variants. Further described are methods of preparing and using such compounds. These growth hormone compounds are based on there althered profile considered particular useful in therapy.

Claims (11)

1. A growth hormone conjugate selected from the group consisting of:

2. The growth hormone conjugate according to claim 1 , wherein the conjugate is

3. The growth hormone conjugate according to claim 1 , wherein the conjugate is

4. The growth hormone conjugate according to claim 1 , wherein the conjugate is

5. The growth hormone conjugate according to claim 1 , wherein the conjugate is

6. The growth hormone conjugate according to claim 1 , wherein the conjugate is

7. The growth hormone conjugate according to claim 1 , wherein the conjugate is

8. The growth hormone conjugate according to claim 1 , wherein the conjugate is

9. The growth hormone conjugate according to claim 1 , wherein the conjugate is

10. The growth hormone conjugate according to claim 1 , wherein the conjugate is

11. The growth hormone conjugate according to claim 1 , wherein the conjugate is

Assignments (1)
CHANGE OF ADDRESS OF ASSIGNEE Recorded Nov 15, 2021
From: NOVO NORDISK HEALTHCARE A/G
To: NOVO NORDISK HEALTHCARE AG
Reel/Frame 058122/0546 →
Priority Claims (1)
EP 10151405 · Jan 22, 2010 · regional
Continuity (3)
Continuation 13522390
Provisional Application 61297305 · Jan 22, 2010
Related Publication 20140107324A1 · Apr 17, 2014