IP Library › Granted Patent US 9,079,877
Granted Patent B2
US 9,079,877 · App. 14/135,753 · Granted Jul 14, 2015

Process for preparing chiral compounds

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Quick Facts
Patent No.
US 9,079,877
App. No.
14/135,753
Granted
Jul 14, 2015
Kind
B2
Abstract

The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.

Claims (13)

1. 2-[2-(4,6-Dihydroxy-tetrahydro-pyran-2-yl)ethyl]-isoindole-1,3-dione.

2. A compound according to claim 1 , wherein said compound is

3. A compound according to claim 1 , wherein said compound is

4. A compound of the formula

5. A compound of the formula

6. A compound of the formula

7. A compound of the formula

8. A compound of the formula

9. A compound of the formula

10. A compound of the formula

11. A compound of the formula

12. A crystalline form of 4-fluoro-alpha-[2-methyl-1-oxopropyl]-gamma-oxo-N, beta-diphenylbenzenebutanamide characterized as having powder X-ray diffraction peaks of about 9.0, 12.7, 20.2, 22.6, and 25.2 degrees two theta.

13. A crystalline form of (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N, 4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide characterized as having powder X-ray diffraction peaks of about 6.3, 12.7, 16.8, 21.1 and 25.5 degrees two theta.

Assignments (2)
CHANGE OF NAME Recorded Oct 31, 2022
From: UPJOHN US 1 LLC
To: VIATRIS SPECIALTY LLC.
Reel/Frame 061808/0420 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2020
From: PFIZER INC.
To: UPJOHN US 1 LLC
Reel/Frame 054293/0154 →