IP Library › Patent Application 14135876
Patent Application
App. No. 14/135,876

SIGNAL-SENSOR POLYNUCLEOTIDES

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Quick Facts
Patent No.
US None
App. No.
14/135,876
Abstract

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.

Claims (4)

1 . An isolated synthetic signal-sensor polynucleotide, wherein said isolated synthetic signal-sensor polynucleotide comprises an mRNA which encodes an oncology-related polypeptide of interest and a sensor sequence comprising SEQ ID NO: 3741.

2 . The isolated synthetic signal-sensor polynucleotide of claim 1 , wherein the open reading frame of the mRNA is codon optimized.

3 . The isolated synthetic signal-sensor polynucleotide of claim 1 , wherein the isolated synthetic signal-sensor polynucleotide comprises at least one chemical modification, wherein the chemical modification is 1-methylpseudouridine.

4 . The isolated synthetic signal-sensor polynucleotide of claim 3 , further comprising the chemical modification 5-methylcytidine.

Assignments (2)
CHANGE OF NAME Recorded Nov 1, 2016
From: MODERNA THERAPEUTICS, INC.
To: MODERNATX, INC.
Reel/Frame 040540/0907 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2014
From: HOGE, STEPHEN G.; DE FOUGEROLLES, ANTONIN; CHAKRABORTY, TIRTHA
To: MODERNA THERAPEUTICS, INC.
Reel/Frame 032030/0745 →