Cation exchange ureteral stent

1. An endoluminal prosthesis for placing in a body passage of a patient, comprising

a ureteral stent, the ureteral stent comprising a tubular housing having a proximal end and a distal end and a lumen longitudinally disposed therethrough,

a plurality of beads disposed within the lumen of the tubular housing, the beads comprising ion exchange resin material,

at least one anchoring mechanism disposed on a distal end of the tubular housing; and

a pair of porous retention screens disposed within the lumen of the ureteral stent,

wherein the pair of retention screens are configured to retain the plurality of beads and allow flow therethrough.

2. The endoluminal prosthesis of claim 1 , further comprising a hydrogel film having ion exchange material disposed on the outer surface of the ureteral stent.

3. The endoluminal prosthesis of claim 1 , wherein a first retention screen is disposed on the distal end of the ureteral stent and a second retention screen is disposed on the proximal end of the ureteral stent.

4. The endoluminal prosthesis of claim 1 , wherein the ion exchange material comprises a sulfopropyl or sulfonate group bonded to a biocompatible polymeric material.

5. The endoluminal prosthesis of claim 1 , wherein the ion exchange resin material is selected from the group consisting of chitosan-carboxymethylcellulose, a zeolite, a phenolsulfonate, an acrylate-divinyl benzene, a sulfonated polystyrene-divinylbenzene, a carboxylic acid resin, a nanoporous silica, cellulose, a phosphate or carbonic cellulose derivative, collagen, a phosphate or carbonic collagen derivative, a methyacrylate polymer, an agarose-polyacrolein, alginate, a polyvinyl alcohol sponge, and EDTA or other metal chelators.

6. The endoluminal prosthesis of claim 1 , wherein the ion exchange resin material is a phosphate or carbonic cellulose derivative.

7. The endoluminal prosthesis of claim 1 , wherein a magnet is disposed on a proximal end of the ureteral stent, the magnet configured to engage an introduction assembly.

8. The endoluminal prosthesis of claim 1 , wherein the beads are in a packed bed configuration.

9. The endoluminal prosthesis of claim 1 , wherein the beads are microporous or nanoporous.

10. A kit for placing an endoluminal prosthesis comprising,

a ureteral stent, the ureteral stent comprising

a tubular housing having a proximal end and a distal end and a lumen longitudinally disposed therethrough,

a plurality of beads disposed within the lumen of the tubular housing, the beads comprising ion exchange resin material, and

at least one anchoring mechanism disposed on a distal end of the tubular housing; and

a pair of porous retention screens disposed within the lumen of the ureteral stent;

an introduction assembly, the introduction assembly comprising

a wire shaft having a proximal end and a distal end and a first magnet connected to the distal end of the wire shaft; and

an access sheath surrounding the ureteral stent and the introduction assembly,

wherein the first magnet is configured to engage with a corresponding magnet on the at least one anchoring mechanism and wherein the pair of at porous retention screens are configured to retain the plurality of beads and allow flow therethrough.

11. The kit of claim 10 , wherein the ureteral stent further comprises a hydrogel film having ion exchange material disposed on the outer surface of the ureteral stent.

12. The kit of claim 10 , wherein the ion exchange material comprises a sulfopropyl or sulfonate group bonded to a biocompatible polymeric material.

13. The kit of claim 10 , wherein the ion exchange resin material is selected from the group consisting of chitosan-carboxymethylcellulose, a zeolite, a phenolsulfonate, an acrylate-divinyl benzene, a sulfonated polystyrene-divinylbenzene, a carboxylic acid resin, a nanoporous silica, cellulose, a phosphate or carbonic cellulose derivative, collagen, a phosphate or carbonic collagen derivative, a methyacrylate polymer, an agarose-polyacrolein, alginate, a polyvinyl alcohol sponge, and EDTA or other metal chelators.

14. The kit of claim 10 , wherein the ion exchange resin material is a phosphate or carbonic cellulose derivative.

15. The kit of claim 10 , wherein the housing of the introducer assembly further includes a spring-loaded piston disposed within an interior surface.

16. A method for implanting an endoluminal prosthesis into a body, comprising,

providing a ureteral stent, the ureteral stent comprising

a tubular housing having a proximal end and a distal end and a lumen longitudinally disposed therethrough,

a plurality of beads disposed within the lumen of the tubular housing, the beads comprising ion exchange resin material,

at least one anchoring mechanism disposed on a distal end of the tubular housing; and

a pair of porous retention screens disposed within the lumen of the ureteral stent;

engaging the ureteral stent with an introduction assembly, the introduction assembly comprising a wire shaft having a proximal end and a distal end and a first magnet connected to the distal end of the wire shaft;

placing a wire guide along a body path to a location desired for the prosthesis,

inserting an access sheath along the wire guide and advancing the access sheath to the desired position;

removing the wire guide;

advancing the ureteral stent within the access sheath to the desired location using a stent positioner; and

at least partially removing the access sheath and deploying the ureteral stent by disengaging the ureteral stent from the introduction assembly,

wherein the pair of porous retention screens are configured to retain the plurality of beads and allow flow therethrough.

17. The method of claim 16 , wherein the ureteral stent further comprises a hydrogel film having ion exchange material disposed on the outer surface of the ureteral stent.

18. The method of claim 16 , wherein the ion exchange material comprises a sulfopropyl or sulfonate group bonded to a biocompatible polymeric material.

19. The method of claim 16 , wherein the ion exchange resin material is selected from the group consisting of chitosan-carboxymethylcellulose, a zeolite, a phenolsulfonate, an acrylate-divinyl benzene, a sulfonated polystyrene-divinylbenzene, a carboxylic acid resin, a nanoporous silica, cellulose, a phosphate or carbonic cellulose derivative, collagen, a phosphate or carbonic collagen derivative, a methyacrylate polymer, an agarose-polyacrolein, alginate, a polyvinyl alcohol sponge, and EDTA or other metal chelators.

20. The method of claim 16 , wherein the ion exchange resin material is a phosphate or carbonic cellulose derivative.