IP Library › Granted Patent US 8,962,566
Granted Patent B2
US 8,962,566 · App. 14/137,090 · Granted Feb 24, 2015

Multi-arm polymeric alkanoate conjugates

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Quick Facts
Patent No.
US 8,962,566
App. No.
14/137,090
Granted
Feb 24, 2015
Kind
B2
Abstract

Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

Claims (4)

1. A pharmaceutical composition comprising a multi-armed polymer conjugate having the structure,

where n ranges from about 40 to about 500, or a pharmaceutically acceptable salt thereof; and

a pharmaceutically acceptable excipient.

2. The composition of claim 1 , wherein the weight average molecular weight of the conjugate is about 20,000 daltons.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 32383, FRAME 0684 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036876/0143 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
SECURITY AGREEMENT Recorded Mar 4, 2014
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 032383/0684 →