Process for producing imide compound
View Patent ↗The present invention provides an excellent industrial process for producing an imide compound hydrochloride. The process for producing an imide compound hydrochloride of the formula (2): or an enantiomer thereof, which comprises treating a compound of the formula (1): or an enantiomer thereof with an aqueous hydrochloric acid solution in a hydrophilic solvent, followed by crystallizing the resultant.
1. A process for producing an imide compound hydrochloride of the formula (2):
or an enantiomer thereof,
which comprises treating a compound of the formula (1):
or an enantiomer thereof with 1.8 to 5.0% aqueous hydrochloric acid solution in acetone, crystallizing the resultant hydrochloride of the formula (2), and isolating the crystallized hydrochloride of the formula (2).
2. The process for producing the imide compound hydrochloride according to claim 1 , wherein the aqueous hydrochloric acid solution is a 3.0-5.0% aqueous hydrochloric acid solution.
3. The imide compound hydrochloride of the formula (2)
which is obtained by the process according to claim 1 or 2.
4. The imide compound hydrochloride as set forth in claim 3, which has a residual acetone content of about 0.1% by weight or less.
5. The imide compound hydrochloride as set forth in claim 3, which has impurities of about 0.1% by weight or less.
6. The imide compound hydrochloride as set forth in claim 3, which has a residual acetone content of about 0.1% by weight or less, and which has impurities of about 0.1% by weight or less.
7. A process for producing an imide compound hydrochloride of the formula (2):
which comprises treating a compound of the formula (1):
with 1.8 to 5.0% aqueous hydrochloric acid solution in acetone, crystallizing the resultant hydrochloride of the formula (2), and isolating the crystallized hydrochloride of the formula (2).
8. The process for producing the imide compound hydrochloride according to claim 7, wherein the aqueous hydrochloric acid solution is a 3.0-5.0% aqueous hydrochloric acid solution.
9. The imide compound hydrochloride of the formula (2)
which is obtained by the process according to claim 7 or 8.
10. The imide compound hydrochloride as set forth in claim 9, which has a residual acetone content of about 0.1% by weight or less.
11. The imide compound hydrochloride as set forth in claim 9, which has impurities of about 0.1% by weight or less.
12. The imide compound hydrochloride as set forth in claim 9, which has a residual acetone content of about 0.1% by weight or less, and which has impurities of about 0.1% by weight or less.