Thermal ablation system with dispensable therapeutic

1. A method for ablating target tissue within a hollow organ, comprising:

heating an ablation fluid ex-vivo to a predetermined temperature;

pumping the heated ablation fluid from a cassette via a fluid delivery lumen into an introducer inserted into a hollow organ containing the target tissue to thermally ablate the target tissue with the heated ablation fluid;

after the ablation fluid has been circulated through the hollow organ, withdrawing the ablation fluid from the hollow organ via a fluid return lumen in the introducer, the fluid return lumen coupled to the cassette; and

pumping a therapeutic agent from the cassette via the fluid delivery lumen into the introducer inserted into the hollow organ.

2. The method according to claim 1 , further comprising the step of, prior to pumping the therapeutic agent, draining the ablation fluid from the cassette.

3. The method according to claim 1 , further comprising, after the therapeutic agent has been circulated through the hollow organ, withdrawing the therapeutic agent from the hollow organ via the fluid return lumen in the introducer.

4. The method according to claim 1 , wherein the ablation fluid is saline.

5. The method according to claim 1 , wherein the therapeutic agent is one of a non-steroidal anti-inflammatory agent, a steroid, an analgesic and an antimicrobial agent.

6. The method according to claim 1 , further comprising filtering the withdrawn ablation fluid.

7. The method according to claim 6 , further comprising reheating the filtered ablation fluid and recirculating the reheated ablation fluid through the hollow organ.

8. The method according to claim 6 , further comprising cooling the filtered ablation fluid and recirculating the cooled ablation fluid through the hollow organ to cool the hollow organ prior to pumping the therapeutic agent therein.

9. An ablation system, comprising:

a console including a pump motor;

a cassette releasably coupleable to the console and including a reservoir configured to receive a fluid from an external source via a fluid supply lumen, a therapeutic agent chamber containing a therapeutic agent, and an impeller interfacing with the pump motor of the console to deliver one of the fluid and the therapeutic agent to a hollow organ via a delivery lumen;

a heating element heating the fluid received within the reservoir such that the fluid is at a desired temperature for thermal ablation of a target tissue within the hollow organ when the fluid is delivered to the hollow organ; and

a return lumen withdrawing one of the heated fluid and the therapeutic agent from the hollow organ to the cassette.

10. The system according to claim 9 , wherein the fluid is saline.

11. The system according to claim 9 , wherein the therapeutic agent is one of a non-steroidal anti-inflammatory agent, a steroid, an analgesic and an antimicrobial agent.

12. The system according to claim 9 , wherein the impeller is magnetically coupled to the pump motor.

13. The system according to claim 9 , further comprising a valve arrangement altering a supply of fluid to the impeller so that, when the valve arrangement is in a first configuration, a first fluid flow path of the cassette in communication with the fluid supply lumen is open and a second fluid flow path of the cassette in communication with the fluid chamber is closed, and when the valve arrangement is in the second configuration, the first fluid flow path is closed and the second fluid flow path is open.

14. The system according to claim 13 , wherein, when the valve arrangement is in the second configuration, the valve arrangement opens a fluid outlet lumen of the fluid chamber so that the therapeutic agent flows to the impeller.

15. The system according to claim 13 , wherein, when the valve arrangement is in the second configuration, the valve arrangement closes a fluid supply lumen connecting the cassette to the external fluid source.

16. The system according to claim 13 , wherein the valve arrangement includes at least one pincher valve.

17. The system according to claim 9 , wherein the cassette includes a fluid storing reservoir and a level sensor outputting a signal corresponding to a level of fluid in the reservoir.

18. The system according to claim 17 , wherein the console includes a controller determining a volume of fluid circulating through the cassette as a function of the signal.

19. The system according to claim 9 , further comprising a filter filtering the fluid and the therapeutic fluid when returned to the cassette via a fluid return lumen coupled thereto.

20. The method according to claim 1 , wherein the therapeutic agent is selected from a group consisting of blood products, nutritive solutions, drugs and combinations thereof.

21. The system according to claim 9 , wherein the therapeutic agent is selected from a group consisting of blood products, nutritive solutions, drugs and combinations thereof.