IP Library › Patent Application 14143938
Patent Application
App. No. 14/143,938

OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS

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Quick Facts
Patent No.
US None
App. No.
14/143,938
Abstract

Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.

Claims (2)

1 . An oligomeric compound having the nucleobase sequence of SEQ ID NO: 303, wherein the oligomeric compound comprises 2′-methoxyethoxy (2′-MOE) nucleotides throughout, and wherein each internucleoside linkage is a phosphorothioate linkage.

2 . An oligomeric compound having the nucleobase sequence of SEQ ID NO: 368, wherein the oligomeric compound comprises 2′-methoxyethoxy (2′-MOE) nucleotides throughout, and wherein each internucleoside linkage is a phosphorothioate linkage.